B / 3 : Agents Used In Anemia

Question 1

Types of drugs used in anemia (3)

Answer 1

1. Erythrocyte factor (antianemic agents)
2. Erythropoiesis stimulating agent
3. Myeloid growth factor

Question 2

What are the erythrocyte factor drugs? (3)

Answer 2

1. Iron hydroxyde polymaltose
2. Folic acid
3. Vitamin B12 (cobalamin)

Question 3

Iron hydroxide polymaltose
- MOA
- Indication
- SE
- ROA

Answer 3

• Essential for biosynthesis of heme proteins
• For iron deficiency
• Constipation, discolored stool
• IV for impaired absorption or oral with vitamin C (helps with absorption)

Question 4

Folic acid
- MOA
- Indication
- ROA

Answer 4

• Required for AA metabolism, RBC production
• For pregnancy (supplement) or folic acid deficiency caused by bad diet / malabsorption
• Oral

Question 5

Vitamin B12
- MOA
- Indication
- Extra
- ROA

Answer 5

• Required for RBC production
• For deficiency (megaloblastic anemia) or decreased absorption (pernicious anemia)
• Absorption in stomach via iron-containing food
• IM or oral (IV causes anaphylaxis)

Question 6

Epoetin alpha
- MOA
- Effect
- Indication
- SE
- ROA

Answer 6

• Agonist of erythropoietin R
• Stimulates RBC proliferation and differenciation
• For chronic kidney disease, HF related anemia
• Increased risk of thrombus, fever
• IV or subcutaneous

(epoietin : e(rythro)poietin)

Question 7

Filgrastim
- MOA
- Effect
- Indication
- SE
- ROA

Answer 7

• Stimulate G-CSF receptors
• Stimulates WBC production
• For neutropenia, agranulocytosis, leukemia…
• Flu-like symptoms
• Subcutaneous