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5. Pharmacology B > B / 22 : Anti-inflammatory Agents Inhibiting Bronchial Inflammatory Processes > Flashcards

B / 22 : Anti-inflammatory Agents Inhibiting Bronchial Inflammatory Processes Flashcards

1
Q

What are the most effective anti-inflammatory agents in asthma therapy?

A

Corticosteroids

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2
Q

What are the anti inflammatory agents? (6)

A
  • Prednisolone
  • Methylprednisolone
  • Fluticasone
  • Budesonide
  • Montelukast
  • Omalizumab
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3
Q

Prednisolone, Methylprednisolone
- MOA
- Effect
- Indication
- ROA
- Extra

A
  • Activation of glucocorticoid receptors
  • Systemic anti-inflammatory and immunosuppressive effect
  • For severe persistent asthma and hyperthyroidism
  • Oral, IV
  • Methyl makes it higher efficiency
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4
Q

Dose of methylprednisolone

A

4-250mg

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5
Q

Fluticasone, Budesonide
- MOA
- Effect
- Indication
- SE
- ROA

A
  • Activation of glucocorticoid receptors
  • Anti-inflammatory
  • For bronchial asthma _ allergic rhinitis (budesonide)
  • Oropharyngeal candidiasis
  • Inhalation, nasal spray
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6
Q

Montelukast
- MOA
- Effect
- Indication
- SE
- ROA

A
  • LTD4 receptor antagonist (leukotriene)
  • Decreases inflammation & causes bronchodilation
  • For asthma prophylaxis
  • Headache, nightmares, agitation, suicide
  • Oral

(Lukast : leuko)

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7
Q

Omalizumab
- MOA
- Effect
- Indication
- SE
- ROA

A
  • Anti IgE antibody
  • Inhibits mast cell degranulation via binding IgE
  • Prevents attacks of severe persistent asthma
  • Allergy
  • Parenteral, given every 2-4 weeks
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8
Q

Approaches to treatment of coughs

A
  • Non productive cough : antitussive agents
  • Productive cough : muco-active agents
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9
Q

What are the antitussive agents?

A
  • Codeine
  • Butamirate
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10
Q

Codeine
- MOA
- Effect
- Indication
- ROA

A
  • Mu opioid receptor agonist + decreases the sensibility of cough centers
  • Antitussive + weak analgesic effect
  • For acute and chronic coughs
  • Oral
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11
Q

Butamirate
- MOA
- Effect
- Indication
- ROA

A
  • Non opioid antitussive : decreases sensibility of cough centers
  • Suppress cough reflex, bronchodilation, anti-inflammatory
  • For cough, COPD
  • Oral
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12
Q

Prenoxdiazine
- MOA
- Effect
- Indication
- ROA

A
  • Local receptors in the airway
  • Suppress cough reflex
  • Cough
  • Oral
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13
Q

What are mucoactive drugs?

A
  • Expectorants : promote excretion of mucus
  • Mucolytics : liquefy and loosen mucous secretions
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14
Q

What are the 2 muco-active drugs?

A
  • Acetylcysteine
  • Bromhexine (ambroxol)
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15
Q

Acetylcysteine
- MOA
- Effect
- Indication
- ROA

A
  • Reduce disulfide bonds in mucous matrix
  • Mucolytic
  • For cystic fibrosis, chronic bronchitis (+hepatoprotective)
  • Oral, inhaled
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16
Q

Bromhexine
- MOA
- Effect
- Indication
- ROA

A
  • Increase production of serous fluid in respiratory tract
  • Mucolytic
  • For CF, chronic bronchitis
  • Oral, inhaled

5. Pharmacology B (34 decks)

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