B/09 Flashcards
1
Q
What system are BCRA1, BCRA2 and ATM part of?
A
they are part of the homologous recombination repair system
2
Q
What is the role of the ATM protein?
A
it phosphorylates the BRCA1 protein so it can form complexes
3
Q
What type of enzyme is ATM?
A
serine / theronine kinase
4
Q
When is ATM recruited?
A
When there are double stand breaks
5
Q
What does BRCA stand for?
A
breast cancer
6
Q
What does BRCA1 do in the complex?
A
binds directly to DNA
7
Q
Which proteins are in the BRCA complex? (4)
A
- BRAD1
- BRCA1
- BRCA2
- RAD51
8
Q
Neoplasms caused by BRCA1 mutation? (3)
A
- breast carcinoma
- ovarium carcinoma
- prostate carcinoma
9
Q
Neoplams caused by BRCA2 mutation? (5)
A
- breast carcinoma
- ovarium carcinoma
- pancreas carcinoma
- stomach carcinoma
- melanoma
10
Q
Neoplasms / diseases caused by ATM mutation? (3)
A
- Ataxia teleangiectasia
- Breast carcinoma
- Sporadic neoplasms
