B/07

Question 1

What does EGFR stand for?

Answer 1

Epidermal growth factor receptor

Question 2

What type of receptor is EGFR?

Answer 2

receptor tyrosine kinase

Question 3

What happens to EGFR after point mutation?

Answer 3

dimerization possible even without signal, which activates the pathway

Question 4

What pathways are activated when EGFR is activated? (2)

Answer 4

• MAPK

- STAT

Question 5

Results of EGFR pathway activation

Answer 5

• increase transcription
• cell proliferation
• progress in the cell cycle

Question 6

What cancer is caused by EGFR mutation?

Answer 6

Glioma

Question 7

What is the most common BLC2 change?

Answer 7

t(14;18) - region from X18 moves to X14

Question 8

What is the pathway activated by mitochondria for apoptosis?

Answer 8

caspase pathway

Question 9

What happens in BCL2 oncogene transformation?

Answer 9

Overexpression of BCL2 blocks the BAX and BAK dimers and thus apoptosis

Question 10

Which protoooncogenes fuse to transform?

Answer 10

BCR and ABL genes

Question 11

What change is in the ABL/BCR fusion?

Answer 11

t(9;22)

Question 12

What pathways does the BCR-ABL oncoprotein activate? (4)

Answer 12

• JAK
• RAS
• SRC
• P13K

Question 13

Results of the BCR-ABL oncoprotein? (3)

Answer 13

• cell proliferation
• increase cell motility
• inhibition of apoptosis

Question 14

What cancer does BCR/ABL cause?

Answer 14

CML (chronic myeloid leukemia)

Question 15

What cancer does BCL2 cause?

Answer 15

Follicular lymphoma