Axion Guidance & Paper Flashcards
Initial Segment
right at beginning of axon
adjacent to the axon hillock
where growth cone is
axon terminals
steps axons go through to form functional synapses
1 Form Axon
2 Extend growth cone
3 move growth cone through body
4 guide growth cone with molecular cues
5 halt growth cone at precise target
6 axonal pruning
guide post cells
cell surface ligands - attraction and repulsion - resulting in cytoskeleton changes
filopodia
main driver of axion guidance
are slender cytoplasmic projections that extend beyond the leading edge of lamellipodia in migrating cells.
Lamellipodia
cytoskeletal protein actin projections that occur at the leading edge of the migratory cells
Invatapotia
invated, have to get though structral boundry at spinal cord
matrix matrice protease
linked set of polomers
breaks down protines
growth cones have these -> break down so can go through space
small scale pruning
at axion terminal
large sclae pruning
prune entire brance back
why is pruning important
neuodegenration -> if can identifiy pcrocesses -> could stop neurodegeration from happening
SCARM
prevent neurodegernation
if knock out - no degneration of neurons
Neutotropic hypthisis
give neurotrpic factor
present at target
imited with ammount present
get less or more - survive or die baised on factor
why are c elegans a powerfull tool
transparent - can see lables in micoscope
302 neurons
compleet wiring diageam
complete cell linage
easily manipulated
short devolopment time
tilling
avoid two differnt dendrites - contact dependent - than repll back
