Autonomic - Sympathomimetics Flashcards
What are the different receptors for sympathomimetics and what G proteins are they each coupled to?
Alpha 1 - Gq
Alpha 2 - Gi
Beta 1 - Gs
Beta 2 -Gs
(QISS)
What is alpha 1 coupled to and what does it lead to?
Gq —> IP3 cascade —> increased cellular calcium (3 dogs in front of alpha 1 cabin with a calcium bone)
How does activation of alpha 1 receptors affect small arteries, venous return, and mean arterial pressure?
Increase peripheral arterial resistance (vasoconstriction of small arteries), elevates MAP, and increased venous return (Venoconstriction)
(Pulled red and blue leashes of dogs and increasing map camper is holding)
How does alpha 1 activation affect the eyes?
Activates pupillary dilator muscle which cause mydriasis (dilation). (Alpha 1 scout with binocular that look like dilated pupils)
_______ causes urethral sphincter and prostatic smooth muscle contraction.
Alpha 1 activation (alpha 1 scout pulling drawstring of shorts)
What can alpha 1 activation treat?
Hypovolemic shock
What does activation of alpha 2 receptors cause? How do they affect sympathetic tone?
Inhibition of neurotransmitter release. Decreased sympathetic tone. (“No sympathy” graffiti on alpha 2 cabin)
What is the alpha 2 receptor coupled with and what does it lead to?
Coupled with Gi —> IP3-DAG cascade —> decreased cAMP
What activation of alpha 2 receptors lead to?
- decreasing insulting release from pancreatic islet cells (rolled in “welcome inside” mat)
- inhibits lipolysis and release of fatty acids (alpha 2 scout dousing roasting pig)
- decreased aqueous humor production from ciliary body (alpha 2 scout empty water from eyeball hat)
What drug is used to treat chronic open angle glaucoma?
Brimonidine which is an alpha 2 agonist by decreasing aqueous humor production (brim of eyeball hat being held by camper from alpha 2 camp dousing the pig)
What are beta receptors paired with and what does it lead to?
Gs receptors which increased cAMP (I heart band cAMP shirts worn by beta campers)
Where are beta 1 receptors found?
Cardiac myocytes
What does beta 1 activation lead to?
- increase contractility and accelerates HR (elevated heart clock and buff contracted muscle of beta camper with the i love band camp shirt)
- increased cardiac output (heart fire hydrant exploding)
- increases renin release (person holding umbrella under fire hydrant spewing water)
What does beta 2 activation lead to?
- bronchodilation (increased cycle cAMP —> PKA) (beta 2 camper with tuba gasping for air)
- coronary and skeletal muscle vasodilation —> decreases systemic vascular resistance (beta 2 camper with dilated big sleeves)
- decreased diastolic blood pressure (beta 2 camper with dangling diamond earrings)
- stimulates lipolysis and release of free fatty acids from human fat cells (beta 2 camper roasting a pig)
- promotion of gluconeogensis from liver (beta 2 camper producing marshmallows from liver bag)
- increased in insulin release from pancreatic islet cells (welcome inside mat)
- increase aqueous humor production at ciliary body (beta 2 camper filling eyeball balloon)
Side effect of beta 2 activation?
Hypokalemia due to increased insulin activity
What kind of drug is phenylphrine?
Alpha 1 agonist (flannel friends in alpha camp)