Autonomic Nervous System Drugs Flashcards
Nervous System
Central and Peripheral
Central Nervous System
-Brain
-Spinal Cord
Peripheral Nervous System has?
-Autonomic nervous system
-Somatic Nervous system
Two types of Autonomic Nervous System
Sympathetic/Adrenergic and Parasympathetic/Cholinergic
Sends impulses to the CNS
-Afferent (Motor)
-Efferent (Sensory)
Involuntary and Controls and regulates the heart, GI, respiration system, bladder, eyes and glands
-Autonomic NS/ Visceral System
Voluntary, Innervates the skeletal muscles
-Somatic NS
Steps in Synaptic Transmission
Step 1: Transmitter Synthesis
Step 2: Transmitter Storage
Step 3: Transmitter Release
Step 4: Receptor Binding
Step 5: Termination of Transmission
Sympathetic NS terminal Neurotransmitter
Norepinephrine
What are the receptor organ cells of Sympathetic NS?
Alpha and beta
Parasympathetic NS terminal Neurotransmitter
Acetylcholine
Receptor organ cells
Nicotinic and muscarinic
It slows heart rate, increases gastric secretion, empties the bladder and bowel, focuses the eye for near vision, constricts the pupil, and contracts bronchial smooth muscle
Parasympathetic Nervous System
Regulation of the cardiovascular system, regulation of body temperature, and implementation of the fight-or-flight response.
Sympathetic Nervous System
Drugs act though receptors by binding to the receptors to initiate a response or prevent a response
Receptor Theory
Mimic the effect of norepinephrine
Adrenergic Agonist
Stop the sympathetic, Block effect of SNS
Adrenergic Antagonist
Mimic the effect of PNS
Cholinergic Agonist
Block the effect of PNS
Cholinergic Antagonist
Stimulate adrenergic receptors
Sympathomimetic and Adrenergic Agonist
Influence one type of receptor
Selective
Influence all receptors
Non selective
Direct blocking by occupying receptors and indirect blocking by inhibiting release of neurotransmitters
Adrenergic Blockers
A decrease of 20 mmHg or more in SBP, a decrease of 10 mmHg or more in DBP, and/or an increase in the HR of 20 beats/minute or more from supine to standing.
Orthostatic Hypotension
