AUTONOMIC NERVOUS SYSTEM Flashcards
[Afferent/Efferent Neurons]
Sent using afferent nerves from sensations to CNS
Afferent Neurons
[Afferent/Efferent Neurons]
Brings out response from CNS to PNS
Efferent Neurons
[Autonomic/Somatic Division]
Regulates involuntary body responses
Autonomic Division
[Autonomic/Somatic Division]
Voluntary movements by skeletal muscles
Somatic Division
[Afferent/Efferent Neurons]
Cell bodies located in the VENTRAL HORN of the SPINAL CORD
Efferent Neurons
[Afferent/Efferent Neurons]
Cell bodies located OUTSIDE of the SPINAL CORD
Afferent Neurons
[Afferent/Efferent Nerve Fiber]
- Sensory nerve fiber
- Carries signals towards the CNS
- Arrive in the spinal cord via
dorsal root of the spine
Afferent Nerve Fiber
[Afferent/Efferent Nerve Fiber]
- Motor nerve fiber
- Carries nerve pulses awayf rom the CNS to effectors such as glands (visceral) or muscles (somatic)
- Arise from the ventral root of the spine
Efferent Nerve Fiber
Where is the afferent nerve processed?
Brain and spinal cord
Where is the efferent nerve processed?
Somatic and autonomic nervous systems
Which organs does the autonomic nervous system process?
Heart, lungs, genitalia, GIT, glands, etc.
Which is a two-neuron pathway?
a. Autonomic nervous system
b. Somatic nervous system
a. Autonomic nervous system
Which is a one-neuron pathway?
a. Autonomic nervous system
b. Somatic nervous system
b. Somatic nervous system
Which fibers are thin myelinated axons from the CNS?
a. Preganglionic fibers
b. Postganglionic fibers
a. Preganglionic fibers
Which fibers are unmyelinated axons from the CNS?
a. Preganglionic fibers
b. Postganglionic fibers
b. Postganglionic fibers
Which of the ganglionic fibers are slower?
a. Preganglionic fibers
b. Postganglionic fibers
b. Postganglionic fibers
Increases the impulse or action potential transmission
Myelination
Neurons in the autonomic ganglia have ____________.
Dendrites
Sympathetic has a [short/long] preganglionic neuron and a [short/long] postganglionic neuron.
short; long
Parasympathetic has a [short/long] preganglionic nerve and a [short/long] postganglionic nerve.
long; short
What will the parasympathetic system release in the preganglionic neuron & postganglionic neuron?
Both Acetylcholine (ACh)
What will the sympathetic system release in the preganglionic neuron & postganglionic neuron?
Preganglionic = Acetylcholine
Postganglionic = Catecholamines
Norepinephrine and epinephrine that would act on smooth or cardiac muscle
Catecholamines
[Parasympathetic/Sympathetic]
- Rest and digest
- Keeps body energy use low
Parasympathetic
[Parasympathetic/Sympathetic]
- “Fight-or-flight” system
- Involves E activities
Sympathetic
[TRUE/FALSE]
Neurons in the autonomic ganglia have dendrites.
TRUE
What is the dynamic balance between the autonomic branches?
Homeostasis
How many sympathetic chains are found on either side of the spine?
2
This is joined to form a lateral of sympathetic chain
Lateral ganglia
SNS is also known as
Thoracolumbar division
Illustrated by a person who is threatened
Fight or flight system, SNS or adrenaline rush
Modified sympathetic ganglion
Adrenal medulla
[TRUE/FALSE]
Instead of releasing the epinephrine to a target organ, it releases the catecholamines in the blood, which would go to the target tissue and enter the endocrine pathway.
FALSE
What do we secrete when we mediate a short-term response to stress?
Epinephrine or norepinephrine
[TRUE/FALSE]
In SNS, all preganglionic neurons release acetylcholine (ACh), while postganglionic neurons release catecholamines except for the adrenal medulla. Preganglionic nerves release epinephrine in the blood, while in sweat glands, postganglionic neurons release Ach instead of catecholamines.
TRUE
Which system has cranial and sacral nerves associated?
Craniosacral system
Which division keeps body energy low?
Parasympathetic division
Where does sympathetic originate?
Thoracolumbar
Where does parasympathetic originate?
Craniosacral
When two divisions act on different effectors for different effects
Antagonistic effect
When two divisions act on different effectors for unified effect
Cooperative effect
What are the receptors for acetylcholine (ACh)?
Nicotinic receptors (nACh-R) and Muscarinic receptors
It allows a single nervous system to both increase and decrease the activity of a stimulated organ.
Tone
- A special division of the ANS
- It is also called the “mini brain” of GIT since it has its own reflex arcs
Enteric Nervous System
Regulates body fluid homeostasis; sensing the environment within the lumen
Submucosal
Exerts control primarily over digestive tract motility; found in tunica muscularis
Myenteric
It has ACh as the ligand
Cholinergic transmission
2 types of transmission
- Cholinergic transmission
- Adrenergic transmission
Who discovered ACh?
Henry Hallet Dale and Otto Loewi
Where is the site of the ACh release?
- All preganglionic terminals of
ANS - Sympathetic postganglionic
terminals at sweat glands - CNS
Receptor found in ganglia of SNS & PNS; found in adrenal medulla
Nicotinic receptors
What happens when there is too much ACh?
- Channels are perpetually open
- Permanent depolarization
Which is high outside; goes in?
a. Sodium (Na+)
b. Potassium (K+)
a. Sodium (Na+)
Which is high inside; goes out?
a. Sodium (Na+)
b. Potassium (K+)
b. Potassium (K+)
This will not allow ACh to bind
Nicotinic Receptor Antagonists
A neuromuscular blocking agent which can lead to flaccid paralysis
a. Tubocuranine
b. Hexamethonium
a. Tubocuranine
Acts as a competitive antagonist at nicotinic post-ganglionic ACh receptors
a. Tubocuranine
b. Hexamethonium
b. Hexamethonium
G-protein coupled receptors located on smooth and heart muscles
Muscarinic Receptors
- It has alpha, gamma, and beta
- It will be inactive with guanosine diphosphate
G-protein
This will have your Gq
M1, M3 or M5 Receptor Pathway
- Stimulatory
- Has Gs that tries to stimulate adenylate cyclase
M1 Receptor Pathway
- Inhibitory
- Will inhibit the activation of adenylate cyclase
M2 or M4 Receptor Pathway
What does Bordetella pertussis secrete that acts on Gi?
Pertussis toxin
Prototype of muscarinic blockers, which is used for dilating pupils or treating OP poisoning
a. Atropine
b. Ipratropium
c. Scopolamine
a. Atropine
Treatment for asthma and chronic pulmonary disease
a. Atropine
b. Ipratropium
c. Scopolamine
b. Ipratropium
It was used as truth drug in World War II but is now used as treatment for motion sickness
a. Atropine
b. Ipratropium
c. Scopolamine
c. Scopolamine
- Very similar to muscarinic receptors that are also Gq
- Acting on PKC
- Allows calcium release or cellular depolarization
Alpha 1 Adrenergic Receptor Pathway
- Mostly in the heart
- Increases heart rate & contractility
- Renin-release
- Increases Na+ and H2O retention
- Renin-angiotensis-aldosterone system
B1-Adrenergic Receptors
- Smooth muscle cells
- Bronchodilation
- Decrease motility
- Secretion of aqueous humor
- More glucose
- Release of glucagon
B2-Adrenergic Receptors
T1-T4 spinal segments act on B1 receptors increasing heart rate and force of contraction
Antagonistic Effects (Sympathetic)
Vagus nerve acts on M receptors slowing down the heart rate
Antagonistic Effects (Parasympathetic)
Increase salivary MUCOUS secretion
Cooperative Effects (Sympathetic)
Increase salivary SEROUS secretion
Cooperative Effects (Parasympathetic)
Keeps almost all the systemic arterioles constricted to about one-half their maximum diameter
Sympathetic Tone in Heart and Blood Vessels
- Can also shift blood flow from one organ to another as needed
- Prioritization of the blood vessels to skeletal muscles and heart in times of emergency
Sympathetic Tone in Heart and Blood Vessels
Decreasing sympathetic stimulation
Vasodilation
Sympathetic stimulation inhibits gastrointestinal motility
Parasympathetic Tone in Gastrointestinal Tract
Parasympathetic stimulation increases
gastrointestinal peristalsis
- Primarily regulates body fluid homeostasis
- Sensing the environment within the lumen
- Regulating gastrointestinal blood flow
- Controlling epithelial cell function
Submucosal or Meissner’s
Plexus
- Irreversible, non-competitive antagonist
- Treatment of pheochromocytoma
- Tumor of the adrenal medulla
Phenoxybenzamine
- Reversible, competitive antagonist
- Treatment of hypertensive crisis
- Can lead to a heart attack, stroke, or other life-threatening health problems
Phentolamine