Autonomic Adrenergic Pharmacology

Question 0

What adrenergic alpha receptor agonist has selectivity for A1, has potent vasoconstriction, common use as nasal decongestant?

Answer 0

Phenylephrine

Question 1

What are two alpha adrenergic receptor agonists?

Answer 1

Phenylephrine and clonidine

Question 2

What adrenergic alpha receptor agonist has selectivity for A2, used for systemic hypertension, action appears primarily in CNS, reduction in discharge or Preganglionic fibers in splanchnic nerves as well as post ganglionic fibers of cardiac nerves

Answer 2

Clonidine

Question 3

What are two examples of alpha adrenergic receptor antagonists?

Answer 3

Phentolamine and Prazosin

Question 4

What adrenergic alpha receptor antagonist is non selective for A1/A2 and has some use in control of hypertension?

Answer 4

Phentolamine

Question 5

What adrenergic alpha receptor antagonist has A1 selectivity, is used to treat benign prostatic hyperplasia which is a common condition involving the enlargement of the prostate gland and difficulty urinating, alpha receptor in urethra contribute to the resistance of the outflow of urine?

Answer 5

Prazosin

Question 6

In general what is the ending for beta receptor agonists?

Answer 6

OL

Question 7

What are 3 exceptions to the naming for beta receptors that don’t end in enol or erol?

Answer 7

Terbutaline, isoetharine, ritodrine

Question 8

In general what is the ending for beta antagonist drugs?

Answer 8

Olol

Question 9

What are 2 beta receptor agonists that are used in the treatment of Bronchoconstriction in patients with asthma or chronic obstructive pulmonary disease?

Answer 9

Isoproterenol, albuterol

Question 10

What beta receptor agonist used to treat asthma and COPD is non selective for B1/B2 and produces significant CV effects?

Answer 10

Isoproterenol

Question 11

What beta receptor agonist used to treat asthma and COPD has some selectivity for B2 has reduced CV effects is inhaled or taken orally?

Answer 11

Albuterol

Question 12

What adrenergic receptor activation has the effect to relax smooth muscle and decrease airway resistance?

Answer 12

B2

Question 13

Tremor and CV effects of side effects of what type of drugs?

Answer 13

B2 agonists

Question 14

What are 2 examples of Beta receptor antagonist drugs?

Answer 14

Propanolol, atenolol

Question 15

What beta antagonist drug is the prototype for the class and is non selective for B1/B2?

Answer 15

Propranolol

Question 16

What beta receptor antagonist has some selectivity for B1?

Answer 16

Atenolol

Question 17

What are used extensively in the treatment of hypertension and angina, don’t cause reduction in blood pressure in patients w/ normal blood pressure, but do lower blood pressure in patients w/ hypertension, adequacy of block can be assessed by measuring suppression of exercise induced tachycardia?

Answer 17

Beta receptor antagonists

Question 18

What are some contraindications of beta receptor antagonists?

Answer 18

B2 blockade in bronchial smooth muscle (B1 selective helpful), block of generation of glucose from glycogen in diabetics, delay recovery from insulin induced hypoglycemia (B1 selective preferable)

Question 19

What are 4 indirect acting sympothomimics?

Answer 19

Amphetamine, cocaine, tyramine, ephedrine

Question 20

What sympathomimetic displaces NE from vesicles and increases it’s release and has the therapeutic effects of suppression of appetite, narcolepsy, and ADD also can cause sympathetic mimicry, CV effects and crisis?

Answer 20

Amphetamine

Question 21

What indirect acting sympathomimetic blocks monoamine transmitter re uptake, increasing synaptic concentrations has uses in ear, nose and throat surgical procedures topically and induces intense vasoconstriction effect to limit bleeding but also has the deleterious effects of seizures, hypertensive crisis-cerebral hemorrhage, cardiac arrhythmia’s, myocardial ischemia ( in situ thrombosis of coronary spasm)

Answer 21

Cocaine

Question 22

What sympathomimetic is found in fermented/aged foods and causes release of catecholines from vesicles increasing synaptic concentrations, normally readily metabolized by the liver, creates strong sympathomimetic responses in patients taking MAO inhibitors?

Answer 22

Tyramine

Question 23

What sympathomimetic has mixed actions of causing release if catecholamines from vessels and directly activating adrenergic receptors, it was traditional used for asthma and pseudophedrine as a decongestant, used abusively for weight loss, to make methamphetamine, body building with significant risk of CV damage?

Answer 23

Ephedrine