Autoimmune Liver Disease

Question 1

what are the 3 main autoimmune liver diseases

Answer 1

autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis

Question 2

which autoimmune liver disease is more common in men

Answer 2

primary sclerosing cholangitis

Question 3

which immunoglobulin is raised in autoimmune hepatitis

Answer 3

IgG

Question 4

which immunoglobulin is raised in PBC

Answer 4

IgM

Question 5

what antibodies is positive in primary sclerosing cholangitis that is also raised in glomerular vasculitis

Answer 5

pANCA

Question 6

presentation of autoimmune hepatitis

Answer 6

general symptoms
hepatomegaly
jaundice
ascites
spider naevi
encephalopathy and splenomegaly

Question 7

how can autoimmune hepatitis be distinguished from viral hepatitis

Answer 7

serum autoantibodies

Question 8

what investigation is necessary to diagnose autoimmune hepatitis

Answer 8

a biopsy

Question 9

what condition can hepatitis and PBC both lead to

Answer 9

cirrhosis

Question 10

treatment of autoimmune hepatitis

Answer 10

steroids

Question 11

immunosuppressants in liver transplant

Answer 11

tacrolimus or cyclosporin

Question 12

what is primary biliary cholangitis

Answer 12

autoimmune inflammation of the intrahepatic bile ducts

Question 13

pathogenesis of PBC into cirrhosis

Answer 13

bile duct inflammation –> build up of bile and toxins –> hepatocyte damage –> cirrhosis

Question 14

the 3 autoimmune diseases and their serology things

Answer 14

hepatitis - IgG
PBC - IgM
PSC - pANCA

Question 15

imaging test to show up primary sclerosing cholangitis

Answer 15

MRCP

Question 16

what is cholestasis

Answer 16

reduction or stoppage of bile flow somewhere between hepatocytes and duodenum

Question 17

bilirubin consequence of cholestasis

Answer 17

bilirubin escapes into bloodstream and accumulates. Gets excreted in urine and stools show fat malabsorption

Question 18

surgical treatment for primary sclerosing cholangitis

Answer 18

stent, transplant

Question 19

what is primary sclerosing cholangitis

Answer 19

inflammation and scarring of bile ducts

Question 20

complications of PSC

Answer 20

liver failure
bile duct/liver tumour
infection

Question 21

who is PSC more common in

Answer 21

men