Autoimmune Disorders Flashcards
What are the 2 groups of mechanism of self-tolerance?
Central tolerance
Peripheral tolerance
Central tolerance
Immature self-reactive B/T lymphocytes
Clones that recognize self ag during their matuıration are killed
Peripheral tolerance
Several mechanism silence potentially auto reactive T/B cells in peripheral tissues.
How does autoimmunity occurs
1- upregulation of co-stimulators
2- molecular mimicry
Which type of autoimmune diseases are directed against single organ or tissue
Type 1 DM
MS
Which type of autoimmune diseases caused by the immune response against wide spread ag
SLE
RA
Which autoimmune disorders are organ-specific and mediated by ab, immune complexes
Autoimmune hemolytic anemia
Autoimmune thrombocytopenia
Autoimmune strophic gastritis of pernicious anemia
Myasthenia gravis
Graves’ disease
Goodpasture syndrome
Which autoimmune diseases are mediated by T cells and organ specific
Type 1 DM
MS
Which autoimmune diseases are mediated by T cells and systemic
Rheumatoid Arthritis
Systemic sclerosis
Sjörgen syndrome
Which diseases are mediated by ab and systemic
SLE
Hallmark of the SLA
Antinuclear Antibodies (ANA)— Hallmark of this disease
In which autoimmune disease activation of the self reactive lymphocytes occur due to the molecular mimicry of the microbial ag to the self ag
Rheumatic heart disease
How is the effect of SLE to the cardiovascular system
Damage to any layer of the heart
Pericardial movement
Diffuse leaflet thickening
Valvular endocarditis
Non bacterial verrucous endocarditis
Effect of SLE to joints
Non-erosive synovitis
SLE effect on the lungs
Pleuritis
Pleural effusion
Rheumatoid Arthritis
Chronic inflammatory systemic disease
Skin, blood vessel , heart , lung , muscle
Principally attacks joints
Destruction of articulation cartilage
Breakdown of immunologic self-tolerance and chronic inflammation
Tell response
Autoantibodies to autologous IGg in which disease
Rheumatoid arthritis
What does Macrophage produceses in rheumatoid arthritis
IL-1,IL-6,TNF,NO,GF,TGF-B
Pannus formation occur in which disease and what it is
RA
Synovial mass consist of inflammatory cells, granulation tissue, fibroblasts , grows over articulated cartilage , causes erosion
How does RA effect the skin
Rheumatoid nodules
How does RA effect the BV
Rheumatoid vasculitis
What is the physiological feature of Sjörgen syndrome
Dry eyes,dry mouth
Sjörgen syndrome results from
Immunologically mediated destruction of the lacrimal and salivary glands
Lymphocytic infiltration and fibrosis of the lacrimal and salivary glands
What Sjörgen syndrome’s infiltrate contains
Activated CD4+ helper T cells and some B cells
What are the serologic markers of Sjörgen syndrome
Ab directed against two ribonucleoprotein ag : SS-A (Ro) and SS-B (La)
What are the results of Sjörgen syndrome
Periductal and perivascular lymphocytic infiltration
High risk for development of B cell lymphomas
What are the mol that diagnostic for SLE
Ab to dsDNA
Ab to smith ag
What are the results of SLE
Injury caused by immune complex deposition and binding of ab to various cells
Acute necrotizing vasculitis
Fibrinoid deposits in the vessel walls
Which tissues are involved in SLE
Skin, joints, kidney, serosal membranes, heart , every organ in body
