Autoimmune Disorders Flashcards
What are the 2 groups of mechanism of self-tolerance?
Central tolerance
Peripheral tolerance
Central tolerance
Immature self-reactive B/T lymphocytes
Clones that recognize self ag during their matuıration are killed
Peripheral tolerance
Several mechanism silence potentially auto reactive T/B cells in peripheral tissues.
How does autoimmunity occurs
1- upregulation of co-stimulators
2- molecular mimicry
Which type of autoimmune diseases are directed against single organ or tissue
Type 1 DM
MS
Which type of autoimmune diseases caused by the immune response against wide spread ag
SLE
RA
Which autoimmune disorders are organ-specific and mediated by ab, immune complexes
Autoimmune hemolytic anemia
Autoimmune thrombocytopenia
Autoimmune strophic gastritis of pernicious anemia
Myasthenia gravis
Graves’ disease
Goodpasture syndrome
Which autoimmune diseases are mediated by T cells and organ specific
Type 1 DM
MS
Which autoimmune diseases are mediated by T cells and systemic
Rheumatoid Arthritis
Systemic sclerosis
Sjörgen syndrome
Which diseases are mediated by ab and systemic
SLE
Hallmark of the SLA
Antinuclear Antibodies (ANA)— Hallmark of this disease
In which autoimmune disease activation of the self reactive lymphocytes occur due to the molecular mimicry of the microbial ag to the self ag
Rheumatic heart disease
How is the effect of SLE to the cardiovascular system
Damage to any layer of the heart
Pericardial movement
Diffuse leaflet thickening
Valvular endocarditis
Non bacterial verrucous endocarditis
Effect of SLE to joints
Non-erosive synovitis
SLE effect on the lungs
Pleuritis
Pleural effusion