Autoimmune Diseases

Question 0

What is the incidence of SLE?

Answer 0

1/2500 Americans (common)

Question 1

What does SLE stand for?

Answer 1

Systemic Lupus Erythematous

Question 2

What is the the fundamental defect in SLE?

Answer 2

Failure to maintain self-tolerance

Question 3

What are environmental factors for SLE?

Answer 3

Female sex hormones, UV light, and drugs (procainamide and hydralazine)

Question 4

What are the principle targets of SLE?

Answer 4

Skin, kidneys, joints, heart, and serosal membranes

Question 5

What are the four most prevalent clinical manifestation of SLE?

Answer 5

Hematologic (100%), arthritis (90%), skin (85%), and fever (83%)

Question 6

What are the 11 diagnostic criteria for SLE?

Answer 6

Malar rash, discoid rash, photosensitivity, oral ulcers, arthritis, serositis, renal disorder, neurological disorder, blood disorder, immunologic disorder, antinuclear antibody

Question 7

What percent of SLE patients have a positive ANA?

Answer 7

50%

Question 8

What are the five treatments discussed for SLE?

Answer 8

NSAIDs, antimalarials (hydroxychloroquine), corticosteroids (prednisone), rituximab, immunosuppressive therapies (methotrexate, azathioprine)

Question 9

What kind of drug is rituximab?

Answer 9

Anti-CD20, trade name Rituxan

Question 10

What diseases are associated with the B27 allele in MHC?

Answer 10

Acute uveitis, ankylosing spondylitis (84.4x)

Question 11

What diseases are associated with the DQ allele in HLA?

Answer 11

Diabetes, rheumatoid arthritis, and systemic lupus erythematous

Question 12

What diseases are associated with the DR alleles of HLA?

Answer 12

Chronic active hepatitis, rheumatoid arthritis, type one diabetes, temporal arteritis, Graves’ disease, and multiple sclerosis