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Step 1 > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Anti-ACh receptor

A

Myasthenia Gravis

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2
Q

Anti-basement membrane

A

Goodpasture syndrome

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3
Q

Anticardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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4
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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5
Q

Anti-desmoglein (Anti-desmosome)

A

Pemphigus vulgaris

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6
Q

Anti-dsDNA, anti-Smith

A

SLE

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7
Q

Anti-glutamic acid decarboxylase (GAD-65)

A

Type I DM

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8
Q

Antihemidesmosome

A

Bullous pemphigoid

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9
Q

Anti-histone

A

Drug-induced lupus

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10
Q

Anti-Jo-1, Anti-SRP, Anti-Mi-2

A

Polymyositis, dermatomyositis

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11
Q

Antimicrosomal, Antithyroglobulin

A

Hashimoto thyroiditis

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12
Q

Antimitochondrial

A

Primary biliary cirrhosis

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13
Q

Antinuclear (ANA)

A

SLE, nonspecific

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14
Q

Antiparietal cell

A

Pernicious anemia

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15
Q

Antiphospholipase A2 receptor

A

Primary membranous nephropathy

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16
Q

Anti-Scl-70 (Anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

17
Q

Anti-smooth muscle

A

Autoimmune hepatitis type I

18
Q

Anti-SSA, Anti-SSB (Anti-Ro, Anti-La)

A

Sjogren syndrome

19
Q

Anti-TSH receptor

A

Graves disease

20
Q

Anti-U1 RNP (ribonucleoprotein)

A

Mixed connective tissue disease

21
Q

Voltage-gated calcium channel antibodies

A

Lambert-Eaton syndrome

22
Q

IgA Anti-endomysial, IgA Anti-tissue transglutaminase

A

Celiac disease

23
Q

MPO-ANCA/p-ANCA

A

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

24
Q

PR3-ANCA/c-ANCA

A

Granulomatosis with polyangiitis (Wegener’s syndrome)

25
Q

Rheumatoid factor (IgM antibody that targets IgG Fc region), Anti-CCP (more specific)

A

Rheumatoid arthritis

26
Q

HLA-A3

A

Hemochromatosis

27
Q

HLA-B8

A

Addison disease, myasthenia gravie

28
Q

HLA-B27

A

Psoriatic arthritis, Ankylosing spondylitis, IBD-associated arthritis, Reactive arthritis (Reiter’s syndrome)

29
Q

HLA-DQ2/DQ8

A

Celiac disease

30
Q

HLA-DR2

A

Multiple sclerosis, hay fever, SLE, Goodpasture syndrome

31
Q

HLA-DR3

A

Diabetes mellitus type I, SLE, Graves disease, Hashimoto thyroiditis, Addison disease

32
Q

HLA-DR4

A

Rheumatoid arthritis, Diabetes mellitus type I, Addison disease

33
Q

HLA-DR5

A

Pernicious anemia –> Vitamin B12 deficiency, Hashimoto thyroiditis

Step 1 (8 decks)

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