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Autoantibodies Flashcards

1
Q

Anti-ACh receptor

A

Myasthenia gravis

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2
Q

Anti-basement membrane

A

Goodpasture syndrome

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3
Q

Anticardiolipin, lupus coagulant

A
  • SLE
  • Antiphospholipid syndrome
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4
Q

Anti-dsDNA

A

SLE (nephritis)

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5
Q

Anti-Smith

A

SLE

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6
Q

Anti-glutamic acid decarboxylase (GAD-65)

A

DM type 1

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7
Q

Anti-hemidesmosome

A

Bullous pemphigus

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8
Q

Anti-histone

A

Drug-induced lupus

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9
Q

Anti-Jo-1, anti-SRP, anti-Mi-2

A
  • Polymyositis
  • Dermatomyositis
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10
Q

Antimicrosomal (anti-TPO)

A

Hashimoto’s thyroiditis

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11
Q

Antimitochondrial

A

Primary biliary cirrhosis

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12
Q

Antinuclear antibodies

A

SLE (non-specific)

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13
Q

Anti-parietal cells

A

Pernicious anemia

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14
Q

Anti-Scl-70 (anti-DNA topoisomerase I)

A

Diffuse scleroderma

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15
Q

Anti-smooth msucle

A

Autoimmune hepatitis

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16
Q

Anti-SSA (anti-Ro)

A

Sjogren syndrome

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17
Q

Anti-SSB (anti-La)

A

Sjogren syndrome

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18
Q

Anti-TSH receptor

A

Graves disease

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19
Q

Anti-U1 RNP (ribonucleoprotein)

A

Mixed connective tissue disease

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20
Q

IgA anti-endomysial (anti-tissue transglutaminase)

A

Celiac disease

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21
Q

Anti-gliadin

A

Celiac disease

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22
Q

MPO-ANCA

A
  • Microscopic polyangiitis
  • Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
23
Q

PR3-ANCA

A

Granulomatosis with polyangiitis (Wegener)

24
Q

IgM antibody that targets IgG Fc region

A

Rheumatoid arthritis (rheumatoid factor)

25
Q

Anti-CCP/anti-citrullinated protein antibodies (ACPA)

A

Rheumatoid arthritis

26
Q

Anti-desmoglein

A

Pemphigus vulgaris

27
Q

Anti-centromere

A

CREST scleroderma

28
Q

Myasthenia gravis

A

Anti-ACh receptor

29
Q

Goodpasture syndrome

A

Anti-basement membrane

30
Q
  • SLE
  • Antiphospholipid syndrome
A

Anticardiolipin, lupus coagulant

31
Q

SLE (nephritis)

A

Anti-dsDNA

32
Q

SLE

A

Anti-Smith

33
Q

DM type 1

A

Anti-glutamic acid decarboxylase (GAD-65)

34
Q

Bullous pemphigus

A

Anti-hemidesmosome

35
Q

Drug-induced lupus

A

Anti-histone

36
Q
  • Polymyositis
  • Dermatomyositis
A

Anti-Jo-1, anti-SRP, anti-Mi-2

37
Q

Hashimoto’s thyroiditis

A

Antimicrosomal (anti-TPO)

38
Q

Primary biliary cirrhosis

A

Antimitochondrial

39
Q

SLE (non-specific)

A

Antinuclear antibodies

40
Q

Pernicious anemia

A

Anti-parietal cells

41
Q

Diffuse scleroderma

A

Anti-Scl-70 (anti-DNA topoisomerase I)

42
Q

Autoimmune hepatitis

A

Anti-smooth msucle

43
Q

Sjogren syndrome

A
  • Anti-SSA (anti-Ro)
  • Anti-SSB (anti-La)
44
Q

Graves disease

A

Anti-TSH receptor

45
Q

Mixed connective tissue disease

A

Anti-U1 RNP (ribonucleoprotein)

46
Q

Celiac disease

A
  • IgA anti-endomysial (anti-tissue transglutaminase)
  • Anti-gliadin
47
Q

Microscopic polyangiitis

48
Q

Granulomatosis with polyangiitis (Wegener)

49
Q

Rheumatoid arthritis

A
  • IgM antibody that targets IgG Fc region (Rheumatoid factor)
  • Anti-CCP/anti-citrullinated protein antibodies (ACPA)
50
Q

Pemphigus vulgaris

A

Anti-desmoglein

51
Q

CREST scleroderma

A

Anti-centromere

52
Q

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

53
Q

Anti-thyroglobulin

A
  • Hashimoto
  • Graves

Step 1 (17 decks)

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