Auto I - receptor types Flashcards

1
Q

What are the typical locations for M1

A

CNS neurons, sympathetic postganglionic neurons, some presynaptic sites

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2
Q

What is the result of ligand binding for M1

A

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M3 and M5)

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3
Q

What are the typical locations for M2

A

Myocardium, smooth muscle, some presynaptic sites; CNS neurons

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4
Q

What is the result of ligand binding for M2

A

Opening of potassium channels, inhibition of adenylyl cyclase (same mechanism as M4)
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

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5
Q

What are the typical locations for M3

A

Exocrine glands, vessels (smooth muscle and endothelium); CNS neurons

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6
Q

What is the result of ligand binding for M3

A

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M1 and M5)

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7
Q

What are the typical locations for M4

A

CNS neurons; possibly vagal nerve endings

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8
Q

What is the result of ligand binding for M4

A

Opening of potassium channels, inhibition of adenylyl cyclase (same mechanism as M2)
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

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9
Q

What are the typical locations for M5

A

Vascular endothelium, especially cerebral vessels; CNS neurons

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10
Q

What is the result of ligand binding for M5

A

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M1 and M3)

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11
Q

What are the typical locations for Nicotinic N

A

postganglionic neurons, some presynaptic cholinergic terminals

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12
Q

What is the result of ligand binding for Nicotinic N

A

opening of Na, K channels, depolarization

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13
Q

What are the typical locations for Nicotinic M

A

Skeletal muscle neuromuscular end plates

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14
Q

What is the result of ligand binding for Nicotinic M

A

opening of Na, K channels, depolarization

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15
Q

What are the typical locations for Alpha 1

A

postsynaptic effector cells, especially smooth muscle

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16
Q

What is the result of ligand binding for Alpha 1

A

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium

17
Q

What are the typical locations for Alpha 2

A

presynaptic adrenergic nerve terminals, platelets, adipocytes and smooth muscle

18
Q

What is the result of ligand binding for Alpha 2

A

Inhibition of adenylyl cyclase, decreased cAMP
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

19
Q

What are the typical locations for Beta 1

A

postsynaptic effector cells, especially heart, lipocytes, brain; presynaptic adrenergic and cholinergic nerve terminals, juxtaglomerular apparatus of the renal tubules, cilliary body epithelium

20
Q

What is the result of ligand binding for Beta 1

A

stimulation of adenylyl cyclase, increased cAMP

Gs to AC to cAMP

21
Q

What are the typical locations for Beta 2

A

postsynaptic effector cells, especially smooth muscle and cardiac muscle

22
Q

What is the result of ligand binding for Beta 2

A

stimulation of adenylyl cyclase, increased cAMP, Activates cardiac G1 under some conditions
Gs to AC to cAMP

23
Q

What are the typical locations for Beta 3

A

postsynaptic effector cells, epsecially lipocytes and heart

24
Q

What is the result of ligand binding for Beta 3

A

stimulation of adenylyl cyclase, increased cAMP

Gs to AC to cAMP

25
What are the typical locations for D1 (DA1), D5
Brain; effector tissues, especially smooth muscle of the renal vascular bed
26
What is the result of ligand binding for D1 (DA1), D5
stimulation of adenylyl cyclase, increased cAMP
27
What are the typical locations for D2 (DA2)
Brain; effector tissues, especially smooth muscl, presynaptic nerve terminals
28
What is the result of ligand binding for D2 (DA2)
inhibition of adenylyl cyclase; increased potassium conductance D3
29
What are the typical locations for D3
brain
30
What is the result of ligand binding for D3
Inhibition of adenylyl cyclase D4
31
What are the typical locations for D4
Brain, cardiovascular system
32
What is the result of ligand binding for D4
inhibition of adenylyl cyclase