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Pharm U2 > Auto I - receptor types > Flashcards

Auto I - receptor types Flashcards

1
Q

What are the typical locations for M1

A

CNS neurons, sympathetic postganglionic neurons, some presynaptic sites

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2
Q

What is the result of ligand binding for M1

A

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M3 and M5)

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3
Q

What are the typical locations for M2

A

Myocardium, smooth muscle, some presynaptic sites; CNS neurons

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4
Q

What is the result of ligand binding for M2

A

Opening of potassium channels, inhibition of adenylyl cyclase (same mechanism as M4)
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

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5
Q

What are the typical locations for M3

A

Exocrine glands, vessels (smooth muscle and endothelium); CNS neurons

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6
Q

What is the result of ligand binding for M3

A

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M1 and M5)

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7
Q

What are the typical locations for M4

A

CNS neurons; possibly vagal nerve endings

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8
Q

What is the result of ligand binding for M4

A

Opening of potassium channels, inhibition of adenylyl cyclase (same mechanism as M2)
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

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9
Q

What are the typical locations for M5

A

Vascular endothelium, especially cerebral vessels; CNS neurons

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10
Q

What is the result of ligand binding for M5

A

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M1 and M3)

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11
Q

What are the typical locations for Nicotinic N

A

postganglionic neurons, some presynaptic cholinergic terminals

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12
Q

What is the result of ligand binding for Nicotinic N

A

opening of Na, K channels, depolarization

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13
Q

What are the typical locations for Nicotinic M

A

Skeletal muscle neuromuscular end plates

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14
Q

What is the result of ligand binding for Nicotinic M

A

opening of Na, K channels, depolarization

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15
Q

What are the typical locations for Alpha 1

A

postsynaptic effector cells, especially smooth muscle

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16
Q

What is the result of ligand binding for Alpha 1

A

Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium

17
Q

What are the typical locations for Alpha 2

A

presynaptic adrenergic nerve terminals, platelets, adipocytes and smooth muscle

18
Q

What is the result of ligand binding for Alpha 2

A

Inhibition of adenylyl cyclase, decreased cAMP
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization

19
Q

What are the typical locations for Beta 1

A

postsynaptic effector cells, especially heart, lipocytes, brain; presynaptic adrenergic and cholinergic nerve terminals, juxtaglomerular apparatus of the renal tubules, cilliary body epithelium

20
Q

What is the result of ligand binding for Beta 1

A

stimulation of adenylyl cyclase, increased cAMP

Gs to AC to cAMP

21
Q

What are the typical locations for Beta 2

A

postsynaptic effector cells, especially smooth muscle and cardiac muscle

22
Q

What is the result of ligand binding for Beta 2

A

stimulation of adenylyl cyclase, increased cAMP, Activates cardiac G1 under some conditions
Gs to AC to cAMP

23
Q

What are the typical locations for Beta 3

A

postsynaptic effector cells, epsecially lipocytes and heart

24
Q

What is the result of ligand binding for Beta 3

A

stimulation of adenylyl cyclase, increased cAMP

Gs to AC to cAMP

25
Q

What are the typical locations for D1 (DA1), D5

A

Brain; effector tissues, especially smooth muscle of the renal vascular bed

26
Q

What is the result of ligand binding for D1 (DA1), D5

A

stimulation of adenylyl cyclase, increased cAMP

27
Q

What are the typical locations for D2 (DA2)

A

Brain; effector tissues, especially smooth muscl, presynaptic nerve terminals

28
Q

What is the result of ligand binding for D2 (DA2)

A

inhibition of adenylyl cyclase; increased potassium conductance D3

29
Q

What are the typical locations for D3

A

brain

30
Q

What is the result of ligand binding for D3

A

Inhibition of adenylyl cyclase D4

31
Q

What are the typical locations for D4

A

Brain, cardiovascular system

32
Q

What is the result of ligand binding for D4

A

inhibition of adenylyl cyclase

Pharm U2 (11 decks)

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