Auto I - receptor types Flashcards
What are the typical locations for M1
CNS neurons, sympathetic postganglionic neurons, some presynaptic sites
What is the result of ligand binding for M1
Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M3 and M5)
What are the typical locations for M2
Myocardium, smooth muscle, some presynaptic sites; CNS neurons
What is the result of ligand binding for M2
Opening of potassium channels, inhibition of adenylyl cyclase (same mechanism as M4)
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization
What are the typical locations for M3
Exocrine glands, vessels (smooth muscle and endothelium); CNS neurons
What is the result of ligand binding for M3
Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M1 and M5)
What are the typical locations for M4
CNS neurons; possibly vagal nerve endings
What is the result of ligand binding for M4
Opening of potassium channels, inhibition of adenylyl cyclase (same mechanism as M2)
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization
What are the typical locations for M5
Vascular endothelium, especially cerebral vessels; CNS neurons
What is the result of ligand binding for M5
Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium (same mechanism as M1 and M3)
What are the typical locations for Nicotinic N
postganglionic neurons, some presynaptic cholinergic terminals
What is the result of ligand binding for Nicotinic N
opening of Na, K channels, depolarization
What are the typical locations for Nicotinic M
Skeletal muscle neuromuscular end plates
What is the result of ligand binding for Nicotinic M
opening of Na, K channels, depolarization
What are the typical locations for Alpha 1
postsynaptic effector cells, especially smooth muscle
What is the result of ligand binding for Alpha 1
Gq to PLC to Formation of IP3 and DAG, increased intracellular calcium
What are the typical locations for Alpha 2
presynaptic adrenergic nerve terminals, platelets, adipocytes and smooth muscle
What is the result of ligand binding for Alpha 2
Inhibition of adenylyl cyclase, decreased cAMP
Gi to AC to cAMP decrease
Gi to K chan to Hyperpolarization
What are the typical locations for Beta 1
postsynaptic effector cells, especially heart, lipocytes, brain; presynaptic adrenergic and cholinergic nerve terminals, juxtaglomerular apparatus of the renal tubules, cilliary body epithelium
What is the result of ligand binding for Beta 1
stimulation of adenylyl cyclase, increased cAMP
Gs to AC to cAMP
What are the typical locations for Beta 2
postsynaptic effector cells, especially smooth muscle and cardiac muscle
What is the result of ligand binding for Beta 2
stimulation of adenylyl cyclase, increased cAMP, Activates cardiac G1 under some conditions
Gs to AC to cAMP
What are the typical locations for Beta 3
postsynaptic effector cells, epsecially lipocytes and heart
What is the result of ligand binding for Beta 3
stimulation of adenylyl cyclase, increased cAMP
Gs to AC to cAMP
What are the typical locations for D1 (DA1), D5
Brain; effector tissues, especially smooth muscle of the renal vascular bed
What is the result of ligand binding for D1 (DA1), D5
stimulation of adenylyl cyclase, increased cAMP
What are the typical locations for D2 (DA2)
Brain; effector tissues, especially smooth muscl, presynaptic nerve terminals
What is the result of ligand binding for D2 (DA2)
inhibition of adenylyl cyclase; increased potassium conductance D3
What are the typical locations for D3
brain
What is the result of ligand binding for D3
Inhibition of adenylyl cyclase D4
What are the typical locations for D4
Brain, cardiovascular system
What is the result of ligand binding for D4
inhibition of adenylyl cyclase
