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Pharm U2 > 10) Dermatopathology > Flashcards

10) Dermatopathology Flashcards

1
Q

What is the class for Hydrocortisone

A

Steroid

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2
Q

What are the therapeutics for Hydrocortisone

A

Dermatitis, psoriasis

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3
Q

What are the important side effects for Hydrocortisone

A

Atrophy/thinning of skin (collagen), stretch marks, talangiectasias, acne, cataract or glaucoma if applied near eye

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4
Q

What are the other side effects for Hydrocortisone

A

Systemically, affects hypothalamic-pituitary-adrenal axis –> growth retardation

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5
Q

What are the miscellaneous for Hydrocortisone

A

Seven classes, w/class I being the strongest and class VII being the weakest; side effects may be permanent

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6
Q

What is the class for Cyclosporine

A

Immunosuppressant

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7
Q

What are the therapeutics for Cyclosporine

A

Inflammatory conditions (psoriasis)

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8
Q

What are the important side effects for Cyclosporine

A

Raise blood pressure, damage kidneys if used long-term

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9
Q

What is the class for Methotrexate

A

Folate analog

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10
Q

What is the mechanism for Methotrexate

A

Inhibits DHFR

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11
Q

What are the therapeutics for Methotrexate

A

Inflammatory conditions (psoriasis), conditions needing immunosuppression

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12
Q

What are the important side effects for Methotrexate

A

Hepatotoxicity (develops slowly, can give up to 4.5 g over life); pulmonary toxicity (develops quickly); leukopenia; rarely, renal toxicity

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13
Q

What are the other side effects for Methotrexate

A

Nausea, vomiting

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14
Q

What are the miscellaneous for Methotrexate

A

PO, IM (1/week); any drug increasing unbound protein may cause methotrexate toxicity (sulfa, salicylates, TCN, phenytoin)

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15
Q

What is the mechanism for Biologics

A

Block TNF-a

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16
Q

What are the therapeutics for Biologics

A

Inflammatory conditions, arthritis

17
Q

What are the important side effects for Biologics

A

Few (may unmask neurologic disease, latent infections (must do PPDs), malignancies)

18
Q

What are the miscellaneous for Biologics

A

Costly

19
Q

What is the class for UV light therapy

A

UVA, UVB, UVC

20
Q

What is the mechanism for UV light therapy

A

Immunosuppression of T-cells via type I or type II reactions –> mono- or bifunctional adducts in DNA

21
Q

What are the therapeutics for UV light therapy

A

Inflammatory conditions: atopic dermatitis, CTCL, lichen planus, psoriasis (not useful for non-inflammatory conditions)

22
Q

What are the important side effects for UV light therapy

A

Skin cancer, thinning/leathering of skin

23
Q

What are the miscellaneous for UV light therapy

A

Usually used with psoralens (photosensitizing agents that increase efficacy); phenothiazines, thiazides, sulfonamides, NSAIDs, tetracycline, benzodiazapenes also sensitize skin to light therapy

24
Q

What is the class for Isotretinoin (Accutane)

A

Retinoid

25
Q

What is the mechanism for Isotretinoin (Accutane)

A

Stimulate epithelial cell turnover; also anti-inflammatory

26
Q

What are the therapeutics for Isotretinoin (Accutane)

A

Acne

27
Q

What are the important side effects for Isotretinoin (Accutane)

A

Teratogenic effects (washes out in three weeks)

28
Q

What are the miscellaneous for Isotretinoin (Accutane)

A

Good as adjunct to other therapies

29
Q

What is the class for Acitretin (Soriatane)

A

Retinoid

30
Q

What is the mechanism for Acitretin (Soriatane)

A

Stimulate epithelial cell turnover; also anti-inflammatory

31
Q

What are the therapeutics for Acitretin (Soriatane)

A

Psoriasis

32
Q

What are the important side effects for Acitretin (Soriatane)

A

Teratogenic effects (stays in fat stores for three years)

33
Q

What are the miscellaneous for Acitretin (Soriatane)

A

Good as adjunct to other therapies

Pharm U2 (11 decks)

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