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Pharm U2 > 2) Cholinergic Receptor-Inhibitors > Flashcards

2) Cholinergic Receptor-Inhibitors Flashcards

1
Q

What is the class for Atropine

A

Tertiary amine antimuscarinic

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2
Q

What is the mechanism for Atropine

A

Blocks muscarinic receptors

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3
Q

What are the therapeutics for Atropine

A

Mydriasis; cycloplegia

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4
Q

What are the important side effects for Atropine

A

General block of muscarinic functions

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5
Q

What is the class for Scopolamine (Transderm-Scop)

A

Tertiary amine antimuscarinic

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6
Q

What is the mechanism for Scopolamine (Transderm-Scop)

A

Blocks muscarinic receptors

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7
Q

What are the therapeutics for Scopolamine (Transderm-Scop)

A

Prevent or reduce motion sickness

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8
Q

What are the important side effects for Scopolamine (Transderm-Scop)

A

General block of muscarinic functions

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9
Q

What is the class for Dicyclomine (Bentyl)

A

Tertiary amine antimuscarinic

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10
Q

What is the mechanism for Dicyclomine (Bentyl)

A

Blocks muscarinic receptors

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11
Q

What are the therapeutics for Dicyclomine (Bentyl)

A

Reduce transient hypermotility

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12
Q

What are the important side effects for Dicyclomine (Bentyl)

A

General block of muscarinic functions

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13
Q

What is the class for Tropicamide (Mydriacyl)

A

Tertiary amine antimuscarinic

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14
Q

What is the mechanism for Tropicamide (Mydriacyl)

A

Blocks muscarinic receptors

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15
Q

What are the therapeutics for Tropicamide (Mydriacyl)

A

Mydriasis; cycloplegia

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16
Q

What are the important side effects for Tropicamide (Mydriacyl)

A

General block of muscarinic functions

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17
Q

What are the miscellaneous for Tropicamide (Mydriacyl)

A

Very rapidly metabolized

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18
Q

What is the class for Tolterodine (Detrol)

A

Tertiary amine antimuscarinic

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19
Q

What is the mechanism for Tolterodine (Detrol)

A

Blocks muscarinic receptors

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20
Q

What are the therapeutics for Tolterodine (Detrol)

A

Treat transient cystitis; postoperative bladder spasms; incontinence

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21
Q

What are the important side effects for Tolterodine (Detrol)

A

General block of muscarinic functions

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22
Q

What is the class for Benztropine (Cogentin)

A

Tertiary amine antimuscarinic

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23
Q

What is the mechanism for Benztropine (Cogentin)

A

Blocks muscarinic receptors

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24
Q

What are the therapeutics for Benztropine (Cogentin)

A

Treat manifestations of Parkinson’s disease

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25
Q

What are the important side effects for Benztropine (Cogentin)

A

General block of muscarinic functions

26
Q

What are the miscellaneous for Benztropine (Cogentin)

A

Crosses BBB

27
Q

What is the class for Ipratropium (Atrovent)

A

Quarternary amine antimuscarinic

28
Q

What is the mechanism for Ipratropium (Atrovent)

A

Blocks muscarinic receptors

29
Q

What are the therapeutics for Ipratropium (Atrovent)

A

Bronchodilation in asthma or COPD

30
Q

What are the important side effects for Ipratropium (Atrovent)

A

General block of muscarinic functions

31
Q

What is the class for Tiotropium (Spiriva)

A

Quarternary amine antimuscarinic

32
Q

What is the mechanism for Tiotropium (Spiriva)

A

Blocks muscarinic receptors

33
Q

What are the therapeutics for Tiotropium (Spiriva)

A

Bronchodilation in asthma or COPD

34
Q

What are the important side effects for Tiotropium (Spiriva)

A

General block of muscarinic functions

35
Q

What are the miscellaneous for Tiotropium (Spiriva)

A

Longer acting than ipratropium

36
Q

What is the class for Hexamethonium (Methium)

A

Ganglionic blocker

37
Q

What is the mechanism for Hexamethonium (Methium)

A

Blocks ganglionic (Nn) receptor and sympathetic tone

38
Q

What are the therapeutics for Hexamethonium (Methium)

A

Hypertensive crisis; “Bloodless” field surgery

39
Q

What are the miscellaneous for Hexamethonium (Methium)

A

Rarely used

40
Q

What is the class for Mecamylamine

A

Ganglionic blocker

41
Q

What is the mechanism for Mecamylamine

A

Blocks ganglionic (Nn) receptor and sympathetic tone

42
Q

What are the therapeutics for Mecamylamine

A

Hypertensive crisis; “Bloodless” field surgery

43
Q

What are the miscellaneous for Mecamylamine

A

Rarely used

44
Q

What is the class for Succinylcholine (Anectine)

A

Depolarizing blocker

45
Q

What is the mechanism for Succinylcholine (Anectine)

A

Overstimulation of nicotinic receptor, leading to desensitization of muscle unit to further ACh stimulation

46
Q

What are the therapeutics for Succinylcholine (Anectine)

A

Brief procedures (e.g., tracheal intubation, reset dislocated joints)

47
Q

What are the important side effects for Succinylcholine (Anectine)

A

Respiratory paralysis; disturbance of autonomic function

48
Q

What are the miscellaneous for Succinylcholine (Anectine)

A

Produces flaccid paralysis within 1 minute

49
Q

What is the class for Tubocurarine (Curare)

A

Nondepolarizing blocker

50
Q

What is the mechanism for Tubocurarine (Curare)

A

Blocks nicotinic (Nm) receptor

51
Q

What are the therapeutics for Tubocurarine (Curare)

A

Muscle relaxant for surgery w/o deep anesthesia

52
Q

What are the important side effects for Tubocurarine (Curare)

A

Respiratory paralysis; disturbance of autonomic function

53
Q

What are the miscellaneous for Tubocurarine (Curare)

A

Lasts 30-60 minutes

54
Q

What is the class for Mivacurium (Mivacron)

A

Nondepolarizing blocker

55
Q

What is the mechanism for Mivacurium (Mivacron)

A

Blocks nicotinic (Nm) receptor

56
Q

What are the therapeutics for Mivacurium (Mivacron)

A

Muscle relaxant for surgery w/o deep anesthesia

57
Q

What are the important side effects for Mivacurium (Mivacron)

A

Respiratory paralysis; disturbance of autonomic function

58
Q

What are the miscellaneous for Mivacurium (Mivacron)

A

Rapidly hydrolyzed, short acting

59
Q

What is the class for Botulinum toxin A (Botox)

A

Local paralytic

60
Q

What is the mechanism for Botulinum toxin A (Botox)

A

Blocks vesicle fusion and ACh release on presynaptic terminal by degrading SNAP-25

61
Q

What are the therapeutics for Botulinum toxin A (Botox)

A

Reduce frown lines and wrinkles; achalasia; strabismus; oromandibular dystonia

Pharm U2 (11 decks)

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