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PCOL > AUTACOIDS > Flashcards

AUTACOIDS Flashcards

1
Q

Local hormone produced in tissues rather than in glands.

A

AUTACOIDS

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2
Q

Are locally acting hormone like substance, which originates from different tissue and produce intense biological activities near their site of synthesis or release.

A

AUTACOIDS

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3
Q

Classifications of autacoids:

A

AMINE AUTACOIDS
PEPTIDE AUTACOIDS
EICOSANOIDS

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4
Q

Biogenic amines:

A

(THREE CATECHOLAMINES)
DOPAMINE
NOREPINEPHRINE (NORADRENALINE)
EPINEPHRINE (ADRENALINE)

SEROTONIN
HISTAMINE

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5
Q

Eicosanoids:

A

LEUKOTRIENES
THROMBOXANES
PROSTAGLANDINS
PLATELET ACTIVATING FACTORS

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6
Q

Angiotensin
Kinins-bradykinin and kallikidin
Vasopressin
Vasoactive intestinal peptide
substance P
Slow reacting substance of anaphylaxis

A

POLYPEPTIDE

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7
Q

Is a biogenic substance with one or more anime groups.

A

BIOGENIC AMINE / AMINE AUTACOIDS

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8
Q

They are basic nitrogenous compounds formed mainly by decarboxylation of amino acids or by amination and transamination of aldehydes and ketones.

A

BIOGENIC AMINE

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9
Q

It regulate brain functions such as movement, behavior, emotions, temperature, blood pressure and endocrine secretions.

A

BIOGENIC AMINES

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10
Q

They are chemicals your immune system makes. They act like bouncers at a club.

A

HISTAMINE

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11
Q

They help your body get rid of something that’s bothering you — in this case, an allergy trigger, or “allergen.”

A

HISTAMINES

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12
Q

They start the process that hustles those allergens out of your body or off your skin. They can make you sneeze, tear up, or itch — whatever it takes to get the job done. They are part of you body’s defense system.

A

HISTAMINES

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13
Q

4 types of histamine receptors:

A

H1- RECEPTOR
H2- RECEPTOR
H3- RECEPTOR
H4- RECEPTOR

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14
Q

Drives cellular migration, nociception, vasodilation and bronchoconstriction.

A

H1-RECEPTOR

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15
Q

It modifies gastric acid secretion, airway mucus production, and vascular permeability.

A

H2-RECEPTOR

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16
Q

It plays an important role in neuro-inflammatory diseases.

A

H3- RECEPTOR

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17
Q

Other term for serotonin.

A

5-HYDROXYTRYPTAMINE

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18
Q

It is a monoamine neurotransmitter.

A

SEROTONIN OR 5-HYDROXYTRYPTAMINE

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19
Q

Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.

A

SEROTONIN

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20
Q

It plays several roles in our body, including influencing learning, memory, happiness such as well as regulating body temperature, sleep, sexual behavior and hunger.

A

SEROTONIN

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21
Q

Produce in cells (tissue)

A

AUTACOIDS

22
Q

Where is the autacoid located?

A

MAST CELL

23
Q

Like hormone but not hormone

A

AUTACOIDS

24
Q

Too much histamine can cause?

A

Harmful effect in our body

25
Q

Life threatening allergic action

A

ANAPHYLAXIS

26
Q

difficulty in breathing, bronchoconstriction in bronchi by H1

A

DYSPNEA

27
Q

Effect of H1-receptor

A

ALLERGIC REACTION

28
Q

Sleep disorder

A

NARCOLEPSY

29
Q

Blood (WBC), Basophil, Eosinophils

A

H4-RECEPTOR

30
Q

(Lack of enough serotonin is thought to play a role in depression, anxiety, mania and other health conditions.)

A
31
Q

serotonin is almost exclusively produced in neurons originating in the raphe nuclei located in the midline of the brainstem. These serotonin-producing neurons form the largest and most complex efferent system in the human brain.

A

CENTRAL NERVOUS SYSTEM (CNS)

32
Q

part of the brain where serotonin is?

A

BRAINSTEM

33
Q

Where are 5-HT receptors located?

A

POST-SYNAPTIC ENTERIC AND SENSORY NEURONS

ENTERIC NEURONAL MEMBRANES

VAGUS

GASTRIC ENDOCRINE GLANDS AND IN THE CNS

34
Q

Where is most serotonin found?

A

GUT (INTESTINES)

35
Q

About ____ of serotonin is found in the cells lining your gastrointestinal tract.

A

90%

36
Q

About ___ of serotonin is produced by our brain.

A

10%

37
Q

Is 5-HT the same as serotonin?

A

YES, BECAUSE SERONININ IS ALSO KNOWN AS 5-HYDROXYTRYPTAMINE (5-HT)

38
Q

primarily affects mood, promoting feelings of well-being. It also affects appetite, sleep cycles and pain perception.

A

SEROTONIN / 5-HYDROXYTRYPTAMINE (5-HT)

39
Q

What causes a lack of serotonin?

A

AGE-RELATED HEALTH AND BRAIN CHANGES

CHRONIC STRESS

A LACK EXPOSURE TO NATURAL LIGHT

LACK OF PHYSICAL ACTIVITY

40
Q

6 symptoms of low serotonin levels:

A

• MEMORY PROBLEMS
• FEELING LOW
• CRAVING SWEET FOODS
• HAVING PROBLEM SLEEPING
• FEELING BAD ABOUT YOURSELF
• INCREASED LIBIDO (SEXUAL DESIRE)

41
Q

The most widely used class of antidepressant drugs is commonly referred to as?

A

TRICYCLIC ANTIDEPRESSANTS

42
Q

Is a mechanism to enhance blood flow to areas of the body that are lacking oxygen/or nutrients.

A

VASODILATION

43
Q

(The vasodilation’ “causes a
decrease in systemic vascular resistance (SVR) and an increase in blood flow, resulting in a reduction of blood pressure.)

A
44
Q

are involved in the synthesis of serotonin and other neurotransmitters.

A

FOLIC ACID AND VITAMIN B12

45
Q

has been found in many patients who have depression or decreased attention, concentration, and memory.

A

VITAMIN B12 DEFICIENCY

46
Q

H2 BLOCKERS

A

• CIMETIDINE
• FAMOTIDINE
• NIZATIDINE
• RANITIDINE

47
Q

H3 BLOCKERS:

A

• CLOBENPROPIT
• CIPROXIFAN
• CONESSINE
• BETAHISTINE
• PITOLISANT
• ABT - 239
• A-349
• 821
• THIOPERAMIDE

48
Q

treatment for psychiatric disorder or cognitive disorder

A

THIOPERAMIDE

49
Q

H4 BLOCKERS

A

VUF- 6002

50
Q

orally active and inhibits the activity of both mast cell and eosinophils in vivo, and has anti-inflammatory and anti-hyperallergic effects

A

VUF- 6002

PCOL (5 decks)

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