Atheroma and Thrombosis Flashcards
1
Q
The risk factors for atheroma and thrombosis are categorised into what?
A
Non modifiable and modifiable
2
Q
Pathophysiology of atheroma
A
- Endothelial injury affecting laminar flow
- Endothelium becomes more permeable
- lipid accumulation in intimate
- Lipid to foam cells due to monocyte action = FATTY STREAK
- Foam cells secrete chemokine attracting more cells (monos, macros, lymphs, smooth muscle cells)
- Smooth cells proliferate and secrete CT
- Atherosclerotic plaque formed
3
Q
Difference between clot and thrombus?
A
Thrombus = solidification of blood contents formed in the vessel during life
Clot = usually found on post mortem and lacks platelets
4
Q
Secretion from platelets
A
Alpha granules: fib, fibronectin, PDGF
Dense granules: Chemotactic chemicals
5
Q
Virchaws triad
A
Abnormalities of:
Vessel wall
Blood constituents
Blood flow
6
Q
Sequelae of thrombosis?
A
Occlusion of vessel Resolution incorporation into vessel wall Recanalisation Embolisation
7
Q
Genetic causes of PE
A
FV Leiden
Protein S deficiency
8
Q
Other types of embolism
A
Amniotic fluid: increased uterine pressure Gas Fat Foreign body Tumour
