Astroviridae

Question 1

What family of viruses is second to rotaviruses in causing diarrhea?

Answer 1

Astroviridae

Question 2

In what animals do viruses from the family astroviridae cause fatal disease?

Answer 2

birds

Question 3

What are the two genera of astroviridae and who are the hosts?

Answer 3

Avastrovirus: birds (chicken, duck, turkey)

Mamastroviruses: mammals

Question 4

What shape are viruses in the astroviridae family and are they enveloped?

Answer 4

Star-like appearance
Icosahedral symmetry

Non-enveloped

Question 5

Astroviridae viruses have ______ sense, linear, _______ stranded RNA

Answer 5

Positive sense

single stranded

Question 6

T/F: Astroviridae viruses are resistant to low pH and lipid solvents

Answer 6

TRUE

Question 7

Where do astroviridae viruses replicate in the cell?

Answer 7

Cytoplasm

*direct translation of proteins

Question 8

Who does Turkey astrovirus target?

Answer 8

Young turkeys 1-3weeks old

Question 9

What clinical signs will you see in a turkey with astrovirus?

Answer 9

Mild dz: low mortality but persistent infections = poor growing

Diarrhea, listlessness, nervousness, stunted growth

Question 10

What pathology occurs in turkey astrovirus infections?

Answer 10

Intestines and ceca are dilated and filled with fluid***
Hyperplasia of the crypt enterocytes
*virus replication in enterocytes lining the vili
*maldigestion –> DHR