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MDRS > Asthma > Flashcards

Asthma Flashcards

1
Q

What is Asthma according to canadian thoracic society?

A

“Asthma is an
1) inflammatory disorder of the airways
2)characterized by paroxysmal or persistent symptoms
3)such as dyspnea, chest tightness, wheezing, sputum
production and cough, 4)associated with variable airflow limitation and
5)a variable degree of hyperresponsiveness of airways to endogenous or
exogenous stimuli.”

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2
Q

characteristics of asthma

A

Characterized by bronchial hyperreactivity

reversible airflow obstruction, usually in response to to an allergen (Type I hypersensitivity reaction)

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3
Q

what are the Anatomic Alterations of the Lungs

A

-bronchospasm
- excessive production of thick, white bronchial secretion
- mucous plugging ( excessive, tenacious mucous secretion blocks or “plugs” the airway lumen)
- hyperinflation
- In severe cases, atelectasis caused by mucous
plugging
- Bronchial wall inflammation leading to fibrosis

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4
Q

What is the cause of asthma

A

Genetic susceptibility to allergens, RTI, occupational
and environmental stimuli

trigger leads to

  • Airway inflammation
  • bronchial hypereactivity
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5
Q

What are Risk Factors for Asthma

A

Family (parents or siblings) with Hx

Personal Hx of allergic disease

*trigger can impact development at any age

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6
Q

What is extrinscic factor

A

most frequently caused by an allergy (allergic asthma)

caused by environment or occupation

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7
Q

What is intrinsic factor

A

no specific cause can be ID
usually no personal or family Hx of atopy/allergy
it is most common later in life

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8
Q

What are some host risk factor for developing asthma?

A 
Genetics
Emergency C Section
Gender(male↑in childhood)
Atopy
Hypersensitivity
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9
Q

What are some environmental risk factor for asthma

A 
Indoor/outdoor allergens
Air pollution
Socio economic status
Family size
Obesity
Hygiene hypothesis
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10
Q

What is Atopy

A

genetic predisposition of an
individual to produce high quantities of IgE in
response to allergens in the environment . It is a response to allergens in the environment . It is a
condition for the devpt of allergy

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11
Q

What is hygiene hypothesis

A

: children in a critical stage of
devpt of immune system who are not exposed to
typical infectious agents may more frequently
develop asthma

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12
Q

the relationship between asthma and age group

A

School Age (6-12 years): atopy is a risk factor

Adolescents (13-18): with endocrine changes
more females develop, causing a shift in the
male to female ratio, decreasing non atopic

Adult: can develop asthma at any age but

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13
Q

What are the peak season of asthma

A

1) december
2) 3rd wk of school
3) 39 days
4) 52 days

5) a September spikes happens in all age group

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14
Q

how to classify triggers in asthma

A

inflammatory & non-inflammatory

allergens & irritants

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15
Q

What is the effect of inflammatory trigger ?

A
  1. Last longer without tx than non inflammatory
    2.May not cause symptoms until hrs/days after
    3.Can cause symptoms which may take days to
    weeks to resolve
  • induce inflammation
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16
Q

how does a trigger cause allergic reaction?

A

Allergens cause the allergic cascade of events
linked with antigens and production of IgE

  • a combination of immune mediators cause inflammation
    –>Eosinophils, mast cells, neutrophils, macrophages
    releasing histamine & leukotrienes have been
    –>cytokines: IL-4, 3,5,13 responsible for
    modulating inflammatory and immune cell
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17
Q

What are the non-inflammatory triggers of asthma

A
  1. Cold, dry air
    2.Weather conditions
    3.Physical activity (EIA)
    4.Certain Drugs
    5.Food additives
    6.Hormonal changes
    perimenstrual )
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18
Q

What are the inflammatory triggers of asthma

A 
1.Aeroallergens (animals,
house dust mites,
cockroach, molds &
pollens)
2.Viral Infections
3.Occupational sensitizers
4.Second hand smoke
5.Endotoxin
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19
Q

What is the deal with IgE

A

If you have an allergy, your immune system overreacts to an allergen by producing antibodies called Immunoglobulin E (IgE)

Ige mediates mediates mast cell degranulation
–>release of histamine, prostaglandins, leukotrienes

chemotactic(substance cellular locomotion) factors cause infiltration of neutrophils, eosinophils and lymphocytes

lead to inflammatory response

  • ->bronchoconstriction
  • ->edema
  • ->increase vascular permeasbility
  • ->thick secretion
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20
Q

what are the 3 stages of extrinsic allergy responses

A

Early: within minutes and resolves in an hour

late: several hrs after exposure but lasts
longer. May or many not follow an early
response
*more severe and long lasting

BiPhasic: an early response followed by a late
response

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21
Q

What are the Overall Management of Asthma?

A
  1. Confirm the diagnosis & history with PFT’s for
    objective measures
  2. Self Management Education
  3. Determine minimum medication for control

4.Ensure regular reassessment of asthma
control & follow up

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22
Q

Signs & Symptoms of Asthma

A
  • Frequent episodes of breathlessness, chest
    tightness, wheezing or cough
  • Symptoms worse at night and in the early morning
  • Symptoms develop with viral respiratory tract
    infection, after exercise, or exposure to aero
    allergens or irritants
  • Symptoms develop in young children after playing
    or laughing
  • Symptoms improve with bronchodilators or
    corticosteroids
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23
Q

What is the main goal of asthma managment

A
  • Control the disease and symptoms
  • Prevent exacerbations and minimize risks for
    short and long term complications morbidity
    and mortality
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24
Q

control of daytime symptoms

A

< 4 days/week

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25
Q

control of night time symptoms

A

<1 night/week

26
Q

control of physical activity symptom

A

normal or no symptom at all

27
Q

control of exacerbation

A

mild or infrequent

28
Q

Absence from work or school due

to asthma

A

should be none

29
Q

control for Need for a fast

acting β 2 agonist

A

<4 doses/week

30
Q

control for FEV

1 or PEF

A

> 90% personal

best

31
Q

PEF diurnal variation

A

should be <10

15%

32
Q

control for Sputum Eosinophils*

A

<2

3%

33
Q

what are the test used in diagnosis and monitoring of asthma

A

•Spirometry (pre/post Ventolin)
•Peak Expiratory Flow
•Responsiveness to methacholine, histamine or
exercise challenge
•Positive skin tests with allergens or
measurement of specific IgE in serum
•Sputum Induction looking for Eosinophils

34
Q

What are the 3 pft test that are use for diagnosis asthma

A
  1. (preferred): reversible airway obstruction
  2. Peak expiratory flow variability
  3. Postive methacholine challenge test
35
Q

What are the lab result that confirm diagnosis of asthma

A

Sputum examination

  • Eosinophils
  • Charcot Leyden crystals
  • Casts of mucus from small airways
  • Kirschman spirals
  • IgE level (elevated in extrinsic asthma)
  • Exhaled Nitric Oxide Ξ inflammation
36
Q

What are the self managment of asthma that should be offer to all patient

A

–Identify & avoid irritant & allergic triggers
–Assess inhaler technique at each visit
–Written Action Plans
–Adherence to evidence based management

37
Q

How to control the environment to prevent asthma

A

goal: aimed at reducing exposure to allergens by:

  • remaining inside
  • windows closed
  • AC on
  • Air purifiers & no pets
  • no pets
  • Dust mites: airtight covers on bed & pillow
  • bedroom, chemical agents to kill mites
38
Q

What is Exercise Induced Bronchospasm

A

cooling and drying of airways promotes leukotriene

production

39
Q

What are 3 recommendation in preventing EIA?

A
  • take puffer before exercise
  • stay hydrated
  • warm up
40
Q

What can cause occuptional asthma

A 
• wood dust
• flour
• animal dander (vet clinics)
• latex
di-isocyanates
pine resin
41
Q

What are some consideration in asthma managment

A
  • All asthmatics should avoid aspirin ; suggest Tylenol use
  • patient with pregnancy: 1/3 rd of asthmatics have worse control at this time
  • Theophyllines , beta 2 agonists, & steroids can be used
    without significant risk of fetal abnormalities
  • Sinusitis may cause asthma exacerbation
42
Q

What are included in the pharmacotherapy of asthma

A
  1. beta 2 Adrenergic agonists
  2. Inhaled corticosteriod
  3. Leukotriene inhibitors
  4. Anticholinergics
  5. Anti IgE therapy
  6. Biologics: Interleukin (IL 5) (anti IL 5)
  7. Macrolides
43
Q

what is beta 2 Adrenergic agonists

A
  • rapid, effective bronchodilator

drug of choice

  • EIB
  • emergency relief of bronchospasm
  • use PRN(as needed)

Fxn:
- improve asthma symptoms, not inflammation

44
Q

what is Corticosteroids

A
  • Most effective medication in treatment of asthma
    •Reduces symptoms & mortality (inflammation)
  • used of inhaled steroids for long term treatment
    preferred
45
Q

What is 1 thing about long term use of oral steriods

A
  • Long term use of oral steroids should be restricted to

patients with asthma refractory to other treatment

46
Q

What is 1 thing about Short term oral steroid use during exacerbation

A

reduces severity, duration, & mortality

47
Q

What is the function of Leukotriene inhibitors

A
  • Leukotrienes mediate inflammation & bronchospasm

- effective in controlling mild to moderate asthma

48
Q

What is the function of •

Anticholinergics

A

Can be used as adjunct to first line bronchodilators if there
is inadequate response
–> Tiotropium when added to corticosteroid enhances
asthma control & improve symptoms

49
Q

What is function of Anti IgE therapy?

A

Omalizumab (Xolair) is a monoclonal antibody that blocks
IgE biologic effects
–> Indicated in patients with allergic asthma, poorly
controlled with corticosteroids

50
Q

What is the function of (anti IL 5)

A

monoclonal antibody administered monthly IV
–> may be effective in tx for asthma
exacerbations in severe eosoinophillic asthma (allergic) for >18yrs

51
Q

What is the fxn of Macrolides:

A
  • has anti inflammatory and anti-microbial effect

- chronic use in severe astham decrease the frequency of exacerbations because of decrease in IL 8 and neutrophils (anti

52
Q

What are the reason for poor asthma control

A
  1. insufficient patient education
  2. overuse of beta agonists
  3. inadequate use of asthma medication
53
Q

What are the 3 zones in asthma action plan

A 
green zone
--> no symptoms
yellow zone
--> have asthma symptoms
red zone
--> in danger and need help
54
Q

What is the Emergency Management of Asthma

A
  1. Early & frequent use of aerosolized beta 2 agonists
  2. High dose parenteral corticosteroids
  3. Oxygen therapy for hypoxemia
  4. Antibiotics if evidence of infection
    5.In severe ventilatory failure, use MV with
    permissive hypercapnia: small VT , low rate, PIP
    <50 cm H 2 O to avoid air trapping & barotrauma
55
Q

What are the physical findsing in emergency asthma

A 
Vital Signs (increased)
- Respiratory Rate
- Heart Rate (Pulse)
- Blood Pressure
- Use of accessory muscles of inspiration &amp;
expiration
- Pursed lip breathing
- Increased A P Diameter: barrel chest
- Cough &amp; sputum production
56
Q

What are the physical assessment findsings

A
  • Expiratory prolongation (I:E ratio > 1:3)
  • Decreased tactile and vocal fremitus
  • Hyper resonant percussion noted
  • Diminished breath sounds
  • Diminished heart sounds
  • Wheezing
57
Q

What are the 3 radiologiacl findings

A
  • Increased antero posterior diameter
  • Translucent (dark) lung fields
  • Depressed or flattened diaphragm
58
Q

What is Status Asthmaticus

A

a severe condition in which asthma attacks follow one another without pause

Acute , severe and prolonged asthma attack that
may be fatal
–> a unique finding is silent chest

59
Q

What is the ABG of Status Asthmaticus

A

Acute Ventilatory Failure with Hypoxemia or (Acute Respiratory Acidosis)

ph:decrease
paco2: increase
hco3: increase slightly
Pao2: decrease

60
Q

When to intubate acute asthma

A 
•LOC
•Exhaustion
•Respiratory muscle fatigue/failure
•Severe lactic acidosis
•Refractory acidemia (pH<7.0)
•Inability to oxygenate by mask (SpO 2 <
90%)
•Severe cardiac arrhythmias or ischemia

MDRS (23 decks)

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