Article Final - Alzheimer's & epigenetics Flashcards
1
Q
Describe the distribution pattern of neurofibrillary tangles in Alzheimer’s.
A
- The tangles follow a stereotypical pattern
- Entorhinal complex -> limbic structures (hippocampus) -> neocortically across frontal/temporal/parietal cortex
- Loss of neurons and severity of cognitive impairments in AD correspond closely with the burden of tangle pathology
2
Q
What role does BACE1 play in Alzheimer’s?
A
cleaves amyloid precursor proteins - the rate-limiting stop in alpha-beta production, synaptic dysfunction in AD - amyloid B is thought to be involved in premature synapse death (REVIEW)
3
Q
How many genes showed altered DNA methylation in cells with neurofibrillary tangles compared to control cells?
A
2431 genes were found to be potentially altered by aberrant DNA methylation at enhancer in AD
4
Q
Was the altered genes in AD cause increased methylation or decreased?
A
Decreased?
