Article - Breast Cancer Flashcards
What percentage of breast cancer is hereditary?
5%-10%
Mutations in the ________ and _________ genes account for 60%-80% of inherited breast cancers.
BRCA 1 & BRCA 2
Those with mutated BRCA1 and BRCA 2 genes have a ____% to _______% risk of developing breast cancer.
43% - 84%
Those with mutated BRCA1 and BRCA2 genes have a _____% risk of developing contralateral breast cancer
65%
In this article CPM means?
Contralateral Prophylactic Mastectomy – the removal of contralateral breast tissue that does not have cancerous tissue
Was there a significant difference for individuals who opted for CMP and carried mutated genes from those who did not?
No significant difference
However, the predictors of CPM were different in each group - age & education level
Individuals who were younger than 50 years were more likely or less likely to elect CPM?
More likely
Individuals who had higher educational status were more likely or less likely to elect CPM?
More likely
Patients who had a pathogenic variant identified were more likely or less likely to elect CPM than those with VUS?
More likely
Bilateral prophylactic mastectomy (BPM) reduces the risk of developing breast cancer by more than ___%
90%
What drug can be given to patients who have ER positive tumors? (breast cancer is developed from excessive estrogen)
Tamoxifen
What does Tamoxifen do?
Suppresses / inhibits estrogen
Although there was no significant difference between CPM election for BRCA carriers and non BRCA carriers. Who was more likely to elect CMP?
BRCA carriers
CPM election between BRCA carriers was ____% over 6 months and _____% over 12 months
29.9% and 55.4%
CPM election between non BRCA carriers was _____% over 6 months and ____% over 12 months
36.4% and 43%
