Arthritis Flashcards

1
Q

The articular cartilage starts out perpendicular or parallel

A

Longitudinal

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2
Q

What is the mark that separates for uncalcified and calcified

A

Tide mark

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3
Q

As cartilage is loaded what happens

A

Water is squeezed out until you reach equilibrium

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4
Q

In cartilage what is sucking all the water in

A

Aggrecan

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5
Q

Type 2 collagen is only found

A

Cartilage

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6
Q

Function of chondorcytes

A

Makes and breaks down new matrix

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7
Q

As cartilage is broken down, what is left

A

Keratin sulfate

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8
Q

Common clinical findings of arthritis

A

Lameness, joint effusion, stiffness, decreased activity, decreased joint range of motion and muscle atrophy

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9
Q

Non inflammatory joint disorders

A

Osteoarthritis , trauma, neoplasia

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10
Q

Inflammatory joint disease examples

A

Non infectious and infectious arthritis

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11
Q

2 categories of non infection inflammatory disease

A

Nonerosive and erosive

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12
Q

Lupus is an example of what joint disease

A

Nonerosive

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13
Q

rheumatoid is example of what joint disease

A

Erosive

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14
Q

What should u do before joint tap

A

Radiographs

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15
Q

What do you need for joint tap

A

21 g needle, 3 cc syringe, EDTA tube to collect serum

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16
Q

Describe the clarity of OA

A

Transparent

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17
Q

Describe the clarity of erosive immune mediated arthritis

A

Clear or opaque

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18
Q

Describe the clarity of bacterial

A

Opaque

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19
Q

Viscosity of OA

A

High

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20
Q

Viscosity of erosive immune mediated

A

Low

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21
Q

With osteoarthritis what changes occur

A

All aspects of joint organ

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22
Q

Where does the pain come from with OA

A

Synovitis

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23
Q

What is the first thing to happen with OA

A

Synovitis

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24
Q

Progressive degenerative changes result in

A

Decreased structure and function of cartilage and atrophy of articular tissues

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25
Q

Example of normal forces acting on an abnormal joint

A

Secondary to a developmental condition - hip dysplasia or elbow dysplasia

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26
Q

Abnormal forces acting on a normal joint

A

Trauma - luxation or fracture

27
Q

Clinical signs of OA

A

Joint pain, tenderness, limitation of movement, crepitus, joint effusion, degrees of inflammation

28
Q

What is released during inflammation of OA

A

Destructive cellular enzymes

29
Q

What are the effects of loosing Proteoglycans in OA

A

Softer cartilage which is easier to damage

30
Q

Alteration of preoteoglycans content does what

A

Reduces stiffness

31
Q

Do owners recognize mobility issues in their dogs

A

Probably not

32
Q

Lupus is an example of what type of arthritis

A

Immune - non erosive

33
Q

Poly arthritis is an example of what type of arthritis

A

Immune - non erosive

34
Q

Idiopathic poly arthritis is an example of what type of arthritis

A

Immune - non erosive

35
Q

Plasmacytic lymphocytic gonitis is an example of what type of arthritis

A

Immune - non erosive

36
Q

Drug and vaccine induced arthritis is an example of what type of arthritis

A

Immune - non erosive

37
Q

Gonitis

A

Stifle joint inflammation - boxers

38
Q

What breed is associated with polyarthritis

A

Spaniel breeds

39
Q

What is the most common form of inflammatory polyarthritis

A

Idiopathic polyarthritis

40
Q

Anything that causes an antigen antibody reaction may cause

A

Polyarthritis

41
Q

Type 1 idiopathic polyarthritis

A

Isolated condition

42
Q

type 2 idiopathic polyarthritis

A

Associated with other infections

43
Q

Type 3 idiopathic polyarthritis

A

Associated with GI disease

44
Q

Type 4 idiopathic polyarthritis is associated with

A

Neoplasia of other sites

45
Q

Chief complaint of idiopathic polyarthritis

A

Shifting leg lameness

46
Q

Physical finding of idiopathic polyarthritis is primarily in

A

Distal joints

47
Q

Synovial fluid analysis of idiopathic polyarthritis

A

Turbid, cloudy, low viscosity, water, elevated cell count,

48
Q

What is found in cell content of idiopathic polyarthritis

A

Mature non toxic polymorphonuclear leukocytes, no bacteria

49
Q

Potiental causes of idiopathic polyarthrisi

A

Ehrlichia, RMSF, lymes, heart worms, bacterial infections, drug history

50
Q

First step therapy of idiopathic polyarthritis

A

Doxycycline

51
Q

Second step of idiopathic polyarthritis

52
Q

Third step of therapy for idiopathic polyarthritis

A

Steroid + chemotherapy

53
Q

Examples of immunosuppressive therapy for immune mediated joint disease

A

Pred, leflunomide, azathioprine, cyclosporine, cyclophosphamide

54
Q

Examples of plasmacytic lymphocytic gonitis

A

Canine stifle joint, cranial drawer instability, severe Synovitis

55
Q

What drug can contribute to drug induced arthritis

56
Q

Examples of immune - erosive arthritis

A

Canine RA or late stages SLE

57
Q

Canine Ra is due to

A

Altered IgG

58
Q

Pathophysiology of RA

A

Antibody / antigen complexes are deposited in teh synovium, induce arthritis, leads to cartilage erosion, subchondral lysis, collapse and deformation of joints

59
Q

Examples of bacterial infectious arthritis

A

Direct infection, hematogenous infection, spread from surrounding tissues

60
Q

Synovial fluid for bacterial arthritis

A

Turbid, low viscosity, elevated cell count, toxic WBC, bacteria

61
Q

Rickettsial disease

A

Lymes, RMSF, ehrlichia

62
Q

Testing for Lymes

A

Western Blot test, C6 snap test

63
Q

How do you treat Lyme disease

A

Tetracycline, doxycycline, minocycline, and amoxicillin, erythromycin