Arthritis Flashcards
The articular cartilage starts out perpendicular or parallel
Longitudinal
What is the mark that separates for uncalcified and calcified
Tide mark
As cartilage is loaded what happens
Water is squeezed out until you reach equilibrium
In cartilage what is sucking all the water in
Aggrecan
Type 2 collagen is only found
Cartilage
Function of chondorcytes
Makes and breaks down new matrix
As cartilage is broken down, what is left
Keratin sulfate
Common clinical findings of arthritis
Lameness, joint effusion, stiffness, decreased activity, decreased joint range of motion and muscle atrophy
Non inflammatory joint disorders
Osteoarthritis , trauma, neoplasia
Inflammatory joint disease examples
Non infectious and infectious arthritis
2 categories of non infection inflammatory disease
Nonerosive and erosive
Lupus is an example of what joint disease
Nonerosive
rheumatoid is example of what joint disease
Erosive
What should u do before joint tap
Radiographs
What do you need for joint tap
21 g needle, 3 cc syringe, EDTA tube to collect serum
Describe the clarity of OA
Transparent
Describe the clarity of erosive immune mediated arthritis
Clear or opaque
Describe the clarity of bacterial
Opaque
Viscosity of OA
High
Viscosity of erosive immune mediated
Low
With osteoarthritis what changes occur
All aspects of joint organ
Where does the pain come from with OA
Synovitis
What is the first thing to happen with OA
Synovitis
Progressive degenerative changes result in
Decreased structure and function of cartilage and atrophy of articular tissues
Example of normal forces acting on an abnormal joint
Secondary to a developmental condition - hip dysplasia or elbow dysplasia
Abnormal forces acting on a normal joint
Trauma - luxation or fracture
Clinical signs of OA
Joint pain, tenderness, limitation of movement, crepitus, joint effusion, degrees of inflammation
What is released during inflammation of OA
Destructive cellular enzymes
What are the effects of loosing Proteoglycans in OA
Softer cartilage which is easier to damage
Alteration of preoteoglycans content does what
Reduces stiffness
Do owners recognize mobility issues in their dogs
Probably not
Lupus is an example of what type of arthritis
Immune - non erosive
Poly arthritis is an example of what type of arthritis
Immune - non erosive
Idiopathic poly arthritis is an example of what type of arthritis
Immune - non erosive
Plasmacytic lymphocytic gonitis is an example of what type of arthritis
Immune - non erosive
Drug and vaccine induced arthritis is an example of what type of arthritis
Immune - non erosive
Gonitis
Stifle joint inflammation - boxers
What breed is associated with polyarthritis
Spaniel breeds
What is the most common form of inflammatory polyarthritis
Idiopathic polyarthritis
Anything that causes an antigen antibody reaction may cause
Polyarthritis
Type 1 idiopathic polyarthritis
Isolated condition
type 2 idiopathic polyarthritis
Associated with other infections
Type 3 idiopathic polyarthritis
Associated with GI disease
Type 4 idiopathic polyarthritis is associated with
Neoplasia of other sites
Chief complaint of idiopathic polyarthritis
Shifting leg lameness
Physical finding of idiopathic polyarthritis is primarily in
Distal joints
Synovial fluid analysis of idiopathic polyarthritis
Turbid, cloudy, low viscosity, water, elevated cell count,
What is found in cell content of idiopathic polyarthritis
Mature non toxic polymorphonuclear leukocytes, no bacteria
Potiental causes of idiopathic polyarthrisi
Ehrlichia, RMSF, lymes, heart worms, bacterial infections, drug history
First step therapy of idiopathic polyarthritis
Doxycycline
Second step of idiopathic polyarthritis
Steroid
Third step of therapy for idiopathic polyarthritis
Steroid + chemotherapy
Examples of immunosuppressive therapy for immune mediated joint disease
Pred, leflunomide, azathioprine, cyclosporine, cyclophosphamide
Examples of plasmacytic lymphocytic gonitis
Canine stifle joint, cranial drawer instability, severe Synovitis
What drug can contribute to drug induced arthritis
Sulfa
Examples of immune - erosive arthritis
Canine RA or late stages SLE
Canine Ra is due to
Altered IgG
Pathophysiology of RA
Antibody / antigen complexes are deposited in teh synovium, induce arthritis, leads to cartilage erosion, subchondral lysis, collapse and deformation of joints
Examples of bacterial infectious arthritis
Direct infection, hematogenous infection, spread from surrounding tissues
Synovial fluid for bacterial arthritis
Turbid, low viscosity, elevated cell count, toxic WBC, bacteria
Rickettsial disease
Lymes, RMSF, ehrlichia
Testing for Lymes
Western Blot test, C6 snap test
How do you treat Lyme disease
Tetracycline, doxycycline, minocycline, and amoxicillin, erythromycin