APPROACHES TO TREATMENT- Biological Flashcards
What are the 4 neurophysical treatments?
ECT (Electroconclusive Therapy)
tDCS (Transcranial Direct Current Stimulation)
TMS (Transcranial Magnetic Stimulation)
DBS (Deep Brain Stimulation)
What are the 4 types of psychotropic drugs?
antidepressants
antipsychotics
anxiolytics
psychostimulants
2 types of anxiolytics
BZs & BBs
2 types of antipsychotics
partial agonists & phenothiazines
4 types of antidepressants
Ketamine
SSRIs
Tricyclics
MAOIs
Role of MAOIs
inhibit activity of enzyme monoamine oxidase & increases activity of neurons that utilise noradrenaline/serotonin
LIMITATIONS OF MAOIs
Nasty side effects- cerebral haemorrhage
dangerous interactions with other drugs
Structure of Tricyclics
3 carbon rings
Role of Tricyclics
BLOCKS reuptake of THREE neurotransmitters: serotonin, noradrenaline & dopamine
What are Tricyclics effective for?
effective in treatment of mild & severe depression
LIMITATION OF TRICYCLICS
Toxic effects on the cardiovascular system
What are SSRIs?
Selective Serotonin Reuptake Inhibitors
What are SSRIs effective for?
As effective for mild depression as tricyclics
LIMITATIONS OF SSRIs
Side effects that get looked over/denied:
39% suicidality rate
60% felt emotionally numb
What is Ketamine an alternative for?
It’s an alternative to serotonin related treatments for depression
What does Ketamine act on?
GLUTAMATE
What is GLUTAMATE?
Neurotransmitter that is key in learning, plasticity and motivation
How effective is Ketamine?
Very effective
- immediate effect
- within 2hrs
- effect lasts for up to a week
- effective for patients with long term depression
LIMITATIONS OF KETAMINE
- high risk of addiction
- psychotic side effects
- cystitis- bladder infection
- increase blood pressure rapidly
What do beta blockers do?
BLOCKS effects of adrenaline & noradrenalin
What do Beta Blockers treat?
High blood pressure- from anxiety disorders
What does BZs treat?
severe anxiety
How do BZs act?
facilitates activity of GABA, binds with BZ receptor site & relaxes muscles
LIMITATIONS OF BZs
- Highly ADDICTIVE
- withdrawal effects- tremors/muscle twitching
What do Antipsychotics do?
Reduce psychosis, control delusions