Approach to Sub/Infertility in Dairy & Beef Cows Flashcards

1
Q

what is the logical approach to infertility

A
  1. Breed type: Are we dealing with beef vs. dairy cows?
  2. Age: are we dealing with cow or heifer?
  3. When do fertility problems occur?
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2
Q

what are the issues that beef vs dairy cows commonly get that affects fertility

A

High yielding dairy cow:

  • Cystic ovarian disease
  • Persistent vaginal discharge/endometritis
  • Metabolic diseases

Beef cow:

  • Venereal disease causing pregnancy losses
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3
Q

how does age affect fertility

A

Puberty?

Freemartin?

Infectious causes of pregnancy losses

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4
Q

when do fertility problems occur

A

Estrous cyclicity before service: (submission rate problems)

  • Affecting heat expression
  • Detection
  • Mating

Pregnancy after service: (conception P/AI problems)

  • Leading to inability to establish or maintain a pregnancy
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5
Q

what could underlying causes of a cow that has not expressed estrus and has not ovulated (4)

A

1. True anovulatory anestrus postpartum:

  • Prolonged postpartum or prepubertal
    • Can be nutritional anestrus (negative energy balance post partum)
  • Calving to service interval simply too short
    • Haven’t had time to resume ovulation

2. Just ovulated first time and can’t yet detect CL

  • Early forming CL difficult to see
  • Can take 2-3 d to see them

3. Cystic ovarian disease

4. Developmental abnormalities in heifers

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6
Q

if a cow has not expressed estrus but has ovulated what could be going on, CL detected on ultrasoumd, high progesterone measured in milk or blood (6)

A

1. Estrous detection efficiency

  • Was it missed by staff?

2. First ovulation post partum -pubertal

  • 2-3 hour duration in high yielding dairy cows

3. Calf presence in cow calf cow

  • Suppresses estrus behaviour

4. Stressors inhibit behaviour

  • Environment, flooring etc

5. Luteinization of a DF after GnRH

6. Persistent CL

  • Endometritis/pyometra!
  • Need to scan uterine horn
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7
Q

if a cow is expressing estrus and ovulating what could be going on, CL detected on ultrasound, high progesterone measured in milk or blood (3)

A
  1. Estrous detection accuracy
  2. 1st and 2nd post partum - pubertal ovulation
  3. Simply a short luteal phase, or after PGF2a
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8
Q

if a cow is expressing irregular and not a 21d interval of estrus and not ovulating what could be going on

A

cystic ovarian disease

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9
Q

where do pregnancy failures occur (4)

A
  1. fertilzation failure
  2. failure in maternal recognition of pregnancy
  3. Late embryonic loss
  4. Fetal loss
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10
Q

what % of pregnancy failures occur at fertilization

A

0-10%

~40% occur with heat stress

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11
Q

what % of pregnancy failures occur at failure in maternal recognition of pregnancy

A

10-43%

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12
Q

why does failure at maternal recognition of pregnancy occur

A

Trophoblast protein by the blastocyst that will suppress PGF2alpha

Correlation between the amount of protein and the length of the embryo

  • Depending on the number of cells, higher or lower amounts produced
  • Need a certain amount to get maternal recognition
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13
Q

what % of pregnancy failures occur at late embryonic loss

A

3-4%

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14
Q

how does late embryonic loss occur

A

After maternal recognition has occurred but before fetal development at 6 weeks

Most often after day 24

After PD at 4.5-6% weeks

  • Should be <10% of pregnancy losses to calving, ca. 3-4% from 6 weeks to 3 months
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15
Q

what % of pregnancy loss occurs due to fetal loss

A

5%

After PD at 4.5-6% weeks, should be <10% of pregnancy losses to calving, 3-4% from 6 weeks to 3 months

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16
Q

how is fertilization failure diagnosed

A

Difficult to diagnose

Normal/shortened inter-estrus interval (IOI) (12-24d)

Possible adhesions/genital abnormalities

17
Q

what are the causes of fertilzation failure

A

Farm bull fertility

Timing of AI/insemination technique

Cervical/uterine obstructions (acquired vs congenital)

Genetic abnormalities in oocyte

Delayed ovulation?

18
Q

how does delayed ovulation cause fertilization failure

A

In high yielding dairy cows

Average interval was 27-28h after onset of estrus

But some cows will ovulate later

If they are inseminated with normal protocol (inseminated 12h after end of estrus) then the frozen thawed semen does not last >24h and reduced chances of oocyte being fertilized

19
Q

how is failure of maternal recognition of pregnancy diagnosed

A

Normal/shortened IOI (12-24d)

May have discharge at next heat

20
Q

what are the causes of early embryonic death/failure in maternal recognition of pregnancy (7)

A

1. Ovulation of persistent DF (‘old’ oocyte)

  • Delayed development and embryo quality

2. Chromosomal abnormalities

3. Impaired CL function

  • Slow increase in progesterone, sub-luteal concentration

4. Specific infections:

  • IBR/IPV
  • BVDV
  • Tritrichomonas fetus
  • Campylobacter

5. Unspecific endometritis

  • E. coli
  • T. pyogenes

6. Nutrition: (extremes)

  • Negative energy balance
  • NEFAs
  • Urea
  • Ammonia

7. Heat stress

21
Q

what could be individual animal causes of a repeat breeder (repeats heats at normal intervals and failure to conceive after several AIs)

on clinical exam: non-preg + CL + NAD, low grade vaginitis/cervicitis/grade 1 endometritis, genital abnormalities

A

Luteinization instead of ovulation

Delayed ovulation

Obstructive congenital or acquired genital abnormalities

Short post partum interval

Bad conformation leading to urovagina

22
Q

what could be group animal causes of a repeat breeder (repeats heats at normal intervals and failure to conceive after several AIs)

A

Wrong timing of submission/AI

Reduced bull fertility/semen quality

Faulty AI

Acute severe negative energy balance, other post partum diseases

Sub clinical endometritis/salpingitis (check calving management, metritis)

Specific transmissible infections (check bull)

23
Q

how is late embryonic loss diagnosed

A

Prolonged IOI (>24d)

Possible discharge at next heat

24
Q

what are the causes of late embryonic loss

A

Specific infections:

  • BVDV
  • Campylobacter

Unspecific endometritis/pyometra

  • Scanned

Disease/trauma

Nutrition

  • High protein?

Iatrogenic

  • Drugs (PGF2a if misdiagnosed as not pregnant?)
  • Palpation

Insemination

25
Q

how is fetal loss diagnosed

A

prolonged IOI (>6 weeks)

aborted fetus/fetal membranes/discharge at next heat

26
Q

what are causes of fetal loss

A

Specific viral/bacteria/protozoal infections

Unspecific endometritis/pyometra

  • Tritrichomonas fetus

Disease/trauma

Nutrition

  • Contaminants
  • Toxins
  • Mycotoxins

Stress?

Iatrogenic

  • Drugs
  • Vaccinations

Fetal development abnormalities

27
Q

what are specific viral/bacterial/protozoal infections that can cause fetal loss

A

Neospora

Tritrichomonas

Leptospira

Brucella

Listeria

Salmonella

Chlamydia

IBR

BVD

Blue tongue

Schmallenberg

28
Q

what is the timeline of infectious causes of bovine abortion

A