apoptosis Flashcards
1
Q
what is apoptosis triggered by?
A
cell death signal that can be internal or external
2
Q
what do external death signal molecules do?
A
bind to a surface receptor protein
trigger a protein cascade within the cytoplasm
3
Q
what does an internal death signal result from?
A
DNA damage
4
Q
What does DNA damage cause the activation of?
A
p53 tumour suppressor protein
5
Q
what does both types of death signal result in?
A
Activation of caspases that cause the destruction of the cell
6
Q
why is apoptosis essential during development of an organism?
A
to remove cells no longer required as development progresses
7
Q
when may cells initiate apoptosis?
A
in the absence of growth factors
