Anxiolytic and Sedatives Flashcards
How does alcohol change the affect of anxiolytics
It potentiates their affect
How do benzos and barbiturates compare to GABA MOA
They have receptors adjacent to GABA receptors, which changes the configuration of the GABA receptor
what happens in a barbiturate overdose
coma (death from aspiration of vomitus), respiratory depression
What is an example of an ulta-short acting barbiturate
Thiopental/ Pentothal
What is an example of a short acting barbiturate
Pentobarbital/ Nembutal
What is an example of a medium-acting barbiturate
Butalbital/ Fiorinal
What is an example of a long-acting barbiturate
Phenobarbital/ Luminal
What are the indications of phenobarbital
anti-seizure, sedative
What type of drug is Midazolam (Versed)
short-acting benzodiazapene
What are the indications of diazepam (Valium)
Anxiolytic, sedative, muscle relaxant and seizure control (breakthrough seizure)
What drug type is zolpidem (Ambien)
short-acting non-benzodiazepine hypnotic
What is the MOA of zolpidem (ambien)
potentiates GABA by binding to GABAA receptors at the same location as benzodiazepines
What are risks of taking zolpidem (ambien)
somnabulance with no memory of it (even driving). Take Ambien-CR (controlled release) to help this problem
What drug class is Eszopiclone (Lunesta)
benzodiazepine-like hypnotic
What are side effects of Eszopiclone (Lunesta)
Impaired mentation prior to sedation
