Anxiety Flashcards
List 5 physical symptoms of Anxiety.
- light headedness
- dry mouth
- palpitations
- lump in throat- difficult to breathe or swallow
- nausea or abd. pain
(chest pain, choking muscle ACHES)
What are 5 cognitive symptoms of Anxiety?
- fear of LOSING control
- mentally tense
- loss of concentration
- Derealization (objects feel unreal)
- Depersonalization
(racing thoughts. met-worry, hypervigilance)
What are 5 behavioural symptoms of Anxiety?
- avoidance
- EXAGGERATED response to MINOR surprises
- unable to fall asleep (too worried)
- excessive use of DRUGS/ ALCOHOL
- irritable
(can’t relax)
What is the role of the Amygdala in the stress response?
- acts as the EMOTIONAL filter of the brain for assessing whether sensory material (via the THALAMUS) requires a STRESS or FEAR response
What sites in the brain are responsible for the release of Cortisol by the Adrenal gland?
- Pituitary
- HYPOTHALAMUS
- hippocampus
- amgydala
- —cortisol THROUGH NEGATIVE FEEDBACK will act on ALL these sites
When is anxiety considered as a disorder? (2)
- when the symptoms of anxiety are MORE extreme than normal
- when they occur in an otherwise not anxiety provoking situitation
- a disorder when it causes SIGNIFICANT DISTRESS to social/occupational function
What does a pt with Generalized Anxiety Disorder experience? (3)
- PERSISTANT and generalized anxiety (“free floating”)
- typical anxiety symptoms
- constant fear of loved one falling ill/getting in an accident
What is the criteria for GAD to be diagnosed?
- should be LONG LASTING (most days for at least 6 months)
- no control
- impairs normal function
What are the physical symptoms seen with Generalized Anxiety D.O?
- restlessness
- easily fatigued
- irritable and muscle TENSION
- SLEEP disturbance
- hard to concentrate
Which demographic group is predominantly affected by GAD?
- 20-40 y.o FEMALE
90% of GAD cases have other co-morbidities. Name a few.
- depression
- substance abuse
- other anxiety disorders
What is the treatment for GAD?
- SSRIs is first line; esp. SERTALINE
- CBT
- Pregabalin
- Benzodiazepines for short-term use during CRISISES
What occurs in CBT ?
-it is an evidence based PSYCHOLOGICAL treatment
- based on identifying the pt’s THOUGHTS, COGNITIVE biases and schemas
-
What are schemas?
- an avalanche effect of how people with GAD have this tendency of having negative thoughts ONE after the OTHER.
How is a Panic disorder diff.?
- RECURRENT, Unexpected attacks of SEVERE anxiety
- holds the same physical symptoms of anxiety ( dizziness, chest pain, palpitations, feelings of unreality )
What is common between GAD and Panic disorder?
- similar symptoms
- both NOT due to substance misuse or other medical condition (hyperthyroidism, caffeine intoxic)
What are some ESSENTIAL clinical fts of Panic Disorder? (3)
- 50-67% also have AGORAPHOBIA
- onset late ADOLESCENCE-MID 30s
- high prevalence in cardiology clinic
What are the co-morbidities of Panic disorder?
- depression
- drug and ALCOHOL misuse
-other anxiety d.os
How may panic attacks be triggered?
- in susceptible individuals by INFUSIONS of lactate
- by re-breathing AIR (more CO2)
What is seen on the PET scan during panic attacks>
- increased METABOLISM of the ANTERIOR pole of the TEMPORAL lobe
- parahippocampal gryus
How do you treat panic d.o?
- SSRIs/SNRIs/TRICYCLICS
- CBT
-BENZOs (for panic crisis)
What are the 3 forms of phobias?
- Agoraphobia
- Social Phobia
- Specific Phobia
At what age, do half the cases of agoraphobia present in patients?
50% presents by 20
75% BY EARLY 30s
At what age do social phobias become more apparent?
- 80% by early adolescence
- 75% by early 20s
What is phobia typified with?
- avoidance
- anticipatory ANXIETY
What is Agoraphobia?
- fears of leaving home
- entering shops
- crowd and public places
- travelling alone in trains, buses or planes
What is a key characteristic of agoraphobia?
AVOIDANCE of the the situation; to experience less anxiety
Can Agorabphobia occur secondary to other pathology?
- with depression
- panic d.o
- or just a primary d.o
How may people avoid agoraphobic situations?
- others do shopping for them
- drink alcohol to overcome alone (before socializing)
- shop at 24hr store at night
- internet shopping
What is a specific phobia?
- the marked and PERSISTENT fear that is EXCESSIVE and unreasonable, cued by the anticipation of an object or situation
- pure mention of the phobic stimulus provokes an immediate ANXIETY resp.
Are people with phobias full aware of it?
- they recognize that the fear is EXCESSIVE or UNREASONABLE
How to treat phobias?
- behavioural therapy (EXPOSURE)
- —-graded exposure/ systematic desensitisation ——add in CBT
- SSRIs/ SNRIs
How different is SOCIAL phobia from the rest of the phobias?
- the persistent fear of ONE or more social situations in which the person exposed to UNFAMILIAR people or to possible SCRUTINY by others
- they feel humiliated or embarassed
Where does social phobia usually kick in?
- in small social setting
- they are fine in LARGE crowds
How may the panic attack appear (for social phobia)?
- shaking or blushing
- fear of vomitting
- urgency to DEFECATE or MICTURATE
How may social phobia impact an individual?
- poor school performance
- poor EMPLOYMENT hx
- school refusal
What site in the brain is predominantly activated in social phobia?
- bilateral activation of the AMYGDALA
- increased rCBF (regional cerebral blood flow) to the amygdala (and related LIMBIC areas)
How to rx social phobias?
- CBT
- SSRIs/ SNRIs
-Benzos
What is OCD? (2)
-d.o characterised by obsessive thoughts (intrusive, frequent ideas and impulses) and compulsive acts
What is the MEAN age of onset for OCD?
- 20 y.o
What co-mordidities may OCD be a.w? (4)
- schizo
- tourettes
- body dysmorphic d.o
- eating d.o
- trichtillomania
How are thoughts and acts described as in OCD? (4)
- ideas entering the mind in a stereotyped way (unpleasant, RESISTED, EGO-DYSTONIC)
- repeated, non-functional acts
Top 3 Most common obsessions in OCD?
- Contamination from DIRT, germs, viruses
- Fear of HARM
- excessive concern with SYMMETRY and order
First line rx for OCD according to NICE guideline.
CBT (exposure-response therapy) and/or an SSRI and Clomipramine (TCA)
What is the action of GABA on neurotransmission? (3)
- GABA attaches to GABA-A receptor (inhibitory ionotropic R)
- triggers CHLORIDE ion influx> membrane HYPERPOLARIZATION
> inhibitory post-synaptic potential
What is the axn of benzos?
- enhances the effect of GABA
Potentiation of BZD site brings about what effects?
- relaxation
- anti-convulsant efx
What do antagonists cause at the BZD site?
- anxiety and PRO-convulsants
Why are benzos always intended for use of LESS than 2 weeks?
>sedation (psychomotor impairment) > dependence and abuse > alcohol interaction > may cause CO-morbid depression > withdrawal problems