Anxiety Flashcards

1
Q

List 5 physical symptoms of Anxiety.

A
  1. light headedness
  2. dry mouth
  3. palpitations
  4. lump in throat- difficult to breathe or swallow
  5. nausea or abd. pain

(chest pain, choking muscle ACHES)

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2
Q

What are 5 cognitive symptoms of Anxiety?

A
  1. fear of LOSING control
  2. mentally tense
  3. loss of concentration
  4. Derealization (objects feel unreal)
  5. Depersonalization

(racing thoughts. met-worry, hypervigilance)

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3
Q

What are 5 behavioural symptoms of Anxiety?

A
  • avoidance
  • EXAGGERATED response to MINOR surprises
  • unable to fall asleep (too worried)
  • excessive use of DRUGS/ ALCOHOL
  • irritable

(can’t relax)

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4
Q

What is the role of the Amygdala in the stress response?

A
  • acts as the EMOTIONAL filter of the brain for assessing whether sensory material (via the THALAMUS) requires a STRESS or FEAR response
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5
Q

What sites in the brain are responsible for the release of Cortisol by the Adrenal gland?

A
  • Pituitary
  • HYPOTHALAMUS
  • hippocampus
  • amgydala
  • —cortisol THROUGH NEGATIVE FEEDBACK will act on ALL these sites
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6
Q

When is anxiety considered as a disorder? (2)

A
  • when the symptoms of anxiety are MORE extreme than normal
  • when they occur in an otherwise not anxiety provoking situitation
  • a disorder when it causes SIGNIFICANT DISTRESS to social/occupational function
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7
Q

What does a pt with Generalized Anxiety Disorder experience? (3)

A
  • PERSISTANT and generalized anxiety (“free floating”)
  • typical anxiety symptoms
  • constant fear of loved one falling ill/getting in an accident
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8
Q

What is the criteria for GAD to be diagnosed?

A
  • should be LONG LASTING (most days for at least 6 months)
  • no control
  • impairs normal function
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9
Q

What are the physical symptoms seen with Generalized Anxiety D.O?

A
  • restlessness
  • easily fatigued
  • irritable and muscle TENSION
  • SLEEP disturbance
  • hard to concentrate
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10
Q

Which demographic group is predominantly affected by GAD?

A
  • 20-40 y.o FEMALE
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11
Q

90% of GAD cases have other co-morbidities. Name a few.

A
  • depression
  • substance abuse
  • other anxiety disorders
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12
Q

What is the treatment for GAD?

A
  • SSRIs is first line; esp. SERTALINE
  • CBT
  • Pregabalin
  • Benzodiazepines for short-term use during CRISISES
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13
Q

What occurs in CBT ?

A

-it is an evidence based PSYCHOLOGICAL treatment
- based on identifying the pt’s THOUGHTS, COGNITIVE biases and schemas
-

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14
Q

What are schemas?

A
  • an avalanche effect of how people with GAD have this tendency of having negative thoughts ONE after the OTHER.
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15
Q

How is a Panic disorder diff.?

A
  • RECURRENT, Unexpected attacks of SEVERE anxiety

- holds the same physical symptoms of anxiety ( dizziness, chest pain, palpitations, feelings of unreality )

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16
Q

What is common between GAD and Panic disorder?

A
  • similar symptoms

- both NOT due to substance misuse or other medical condition (hyperthyroidism, caffeine intoxic)

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17
Q

What are some ESSENTIAL clinical fts of Panic Disorder? (3)

A
  • 50-67% also have AGORAPHOBIA
  • onset late ADOLESCENCE-MID 30s
  • high prevalence in cardiology clinic
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18
Q

What are the co-morbidities of Panic disorder?

A
  • depression
  • drug and ALCOHOL misuse

-other anxiety d.os

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19
Q

How may panic attacks be triggered?

A
  • in susceptible individuals by INFUSIONS of lactate

- by re-breathing AIR (more CO2)

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20
Q

What is seen on the PET scan during panic attacks>

A
  • increased METABOLISM of the ANTERIOR pole of the TEMPORAL lobe
  • parahippocampal gryus
21
Q

How do you treat panic d.o?

A
  • SSRIs/SNRIs/TRICYCLICS
  • CBT

-BENZOs (for panic crisis)

22
Q

What are the 3 forms of phobias?

A
  1. Agoraphobia
  2. Social Phobia
  3. Specific Phobia
23
Q

At what age, do half the cases of agoraphobia present in patients?

A

50% presents by 20

75% BY EARLY 30s

24
Q

At what age do social phobias become more apparent?

A
  • 80% by early adolescence

- 75% by early 20s

25
What is phobia typified with?
- avoidance | - anticipatory ANXIETY
26
What is Agoraphobia?
- fears of leaving home - entering shops - crowd and public places - travelling alone in trains, buses or planes
27
What is a key characteristic of agoraphobia?
AVOIDANCE of the the situation; to experience less anxiety
28
Can Agorabphobia occur secondary to other pathology?
- with depression - panic d.o - or just a primary d.o
29
How may people avoid agoraphobic situations?
- others do shopping for them - drink alcohol to overcome alone (before socializing) - shop at 24hr store at night - internet shopping
30
What is a specific phobia?
- the marked and PERSISTENT fear that is EXCESSIVE and unreasonable, cued by the anticipation of an object or situation - pure mention of the phobic stimulus provokes an immediate ANXIETY resp.
31
Are people with phobias full aware of it?
- they recognize that the fear is EXCESSIVE or UNREASONABLE
32
How to treat phobias?
- behavioural therapy (EXPOSURE) - ----graded exposure/ systematic desensitisation ------add in CBT - SSRIs/ SNRIs
33
How different is SOCIAL phobia from the rest of the phobias?
- the persistent fear of ONE or more social situations in which the person exposed to UNFAMILIAR people or to possible SCRUTINY by others - they feel humiliated or embarassed
34
Where does social phobia usually kick in?
- in small social setting | - they are fine in LARGE crowds
35
How may the panic attack appear (for social phobia)?
- shaking or blushing - fear of vomitting - urgency to DEFECATE or MICTURATE
36
How may social phobia impact an individual?
- poor school performance - poor EMPLOYMENT hx - school refusal
37
What site in the brain is predominantly activated in social phobia?
- bilateral activation of the AMYGDALA | - increased rCBF (regional cerebral blood flow) to the amygdala (and related LIMBIC areas)
38
How to rx social phobias?
- CBT - SSRIs/ SNRIs -Benzos
39
What is OCD? (2)
-d.o characterised by obsessive thoughts (intrusive, frequent ideas and impulses) and compulsive acts
40
What is the MEAN age of onset for OCD?
- 20 y.o
41
What co-mordidities may OCD be a.w? (4)
- schizo - tourettes - body dysmorphic d.o - eating d.o - trichtillomania
42
How are thoughts and acts described as in OCD? (4)
- ideas entering the mind in a stereotyped way (unpleasant, RESISTED, EGO-DYSTONIC) - repeated, non-functional acts
43
Top 3 Most common obsessions in OCD?
1. Contamination from DIRT, germs, viruses 2. Fear of HARM 3. excessive concern with SYMMETRY and order
44
First line rx for OCD according to NICE guideline.
CBT (exposure-response therapy) and/or an SSRI and Clomipramine (TCA)
45
What is the action of GABA on neurotransmission? (3)
- GABA attaches to GABA-A receptor (inhibitory ionotropic R) - triggers CHLORIDE ion influx> membrane HYPERPOLARIZATION > inhibitory post-synaptic potential
46
What is the axn of benzos?
- enhances the effect of GABA
47
Potentiation of BZD site brings about what effects?
- relaxation | - anti-convulsant efx
48
What do antagonists cause at the BZD site?
- anxiety and PRO-convulsants
49
Why are benzos always intended for use of LESS than 2 weeks?
``` >sedation (psychomotor impairment) > dependence and abuse > alcohol interaction > may cause CO-morbid depression > withdrawal problems ```