Antivirals

Question 1

Antivirals are virustatic or virucidal?

Answer 1

Virustatic

Question 2

What are the anti herpes drugs

Answer 2

Acyclovir (all but CMV and EBV)
Famcixlovir and valacyclovir
Gangcyclovir
Foscarnet
Cidofovir

Question 3

Indications of acyclovir

Answer 3

Severe cases HSV or varicella in immunocompetent

Herpes infections except EBV and CMV in immunocompromised

Question 4

When are ganciclovir and valganciclovir indicated?

Answer 4

CMV in AIDS patients and prophy for bone marrow transplant patients against CMV

Question 5

Indications for foscarnet

Answer 5

CMV retinitis
Acylcovir resistance

Question 6

HIV treatment acronym

Answer 6

HAART
Highly active antiretroviral therapy

Question 7

When should HIV patients receive antiretroviral therapy?

Answer 7

As soon as dx

Question 8

How many drugs are in a standard highly Active antiretroviral therapy (HAART)?

Answer 8

4

Question 9

What are the preferred HAART regimens);

Answer 9

Bictegravir/ emtricitabine/ tenofovir/ alafenamide

Dolutegravir/ tenofovir/ alafenamide/ emtricitabine

Question 10

How do the following HIV antiretroviral drugs work? - CCR5 inhibitors

Answer 10

Black HIV binding to the ccr5 co receptor

Question 11

How do the following HIV antiretroviral drugs work? - fusion inhibitors

Answer 11

Block HIV from fusing to anchor proteins in the host cell membrane

Question 12

How do the following HIV antiretroviral drugs work? - nucleoside/ nucleotide reverse transcriptase inhibitors and non-nucleiside reverse transcriptase inhibitors

Answer 12

Black HIV from using reverse transcriptase enzyme to convert single stranded RNA into double stranded DNA

Question 13

How do the following HIV antiretroviral drugs work? - integrase inhibitors

Answer 13

Black HIV from using integrase enzymes to insert viral DNA into the host DNA

Question 14

How do the following HIV antiretroviral drugs work? - protease inhibitors

Answer 14

Black proteases that cleave long chains of HIV proteins into smaller HIV proteins that are packed together to form the new HIV virus

Question 15

Nucleoside/nucleotide reverse transcriptase inhibitor developed in 1987 that reduces mortality and opportunistic infections, delays progression to AIDS, and reduces maternal to infant transmission of HIV. However resistance develops

Answer 15

Zidovudine (ZDV or AZT)

Question 16

Nucleotide reverse transcriptase inhibitor that is the backbone of most combination therapy regimens and also helps to suppress Hepatitis B viral DNA replication

Answer 16

Lamivudine and emtricitabine

Question 17

A nucleotide reverse transcriptase inhibitor that is the first choice and has activity against hepatitis B it does have kidney and renal toxicity

Answer 17

Tenofovir

Question 18

Naming convention for protease inhibitors for HIV

Answer 18

End in -navir

Question 19

What are protease inhibitors associated with?

Answer 19

Metabolic abnormalities such as
Dyslipidemia
Insulin resistance
Lipodyatrophy

Question 20

The last ditch HIV treatment due to neutropenia And need for injection

Answer 20

Fashion inhibitor - enfivietide

Question 21

HIV treatment - these drugs are often a first choice when combined with tenofovir and emtricitabine

Answer 21

Integrase imhibitors

Question 22

First line treatment for HIV, integrase inhibitors combined with emtricitabine and tenofovir

Answer 22

PEP for HIV exposurw

Question 23

HIV PEP needlestick

Answer 23

4 wk course of 3+ drugs
Consult HIV specialist for drugs

Question 24

Anti-flu drug given early in course of infection or as PEP during outbreak, but only works for influenza A

Answer 24

Amantadine

Question 25

Class of influenza drugs that work for flu. A, flu B and pandemic strains

Answer 25

Neurominidase inhibitors (oseltamivir, zanamivir, peramivir)

Question 26

Antiviral for RSV in infants and stem cell transplants, Lassa fever, and combination for Hep C

Answer 26

Ribavirin