Antivirals

Question 1

what do antivirals target? tend to have what kind of adverse effects?

Answer 1

steps in viral replication cycle. serious ones

Question 2

antivirals are of limited use in vet med. what do they get used for

Answer 2

herpes keratitis, sometimes EHV-1 in horses

Question 3

acyclovir and remdesivir/GS‐441524 are what kind of antivirals

Answer 3

nucleoside analogues

Question 4

imiquimod is what kind of antiviral

Answer 4

immunomodulator

Question 5

L-lysine: what is it thought to do and why is it controversial

Answer 5

block availability of arginine. uncertain it has any effect

Question 6

acyclovir is used to treat what? and does it have a lot of side effects?

Answer 6

herpesvirus, especially in birds but also horses and dogs. not cats. very selective so few side effects

Question 7

acyclovir is toxic to what species at systemic doses needed to inhibit FHV in vivo

Answer 7

kittycats

Question 8

MOA of acyclovir

Answer 8

resembles guanosine, kets phosphorylated, then when incorporated it terminates DNA elongation preventing DNA strand replication. selective for virus-infected cells

Question 9

what are idoxuridine and trifluridine used to treat

Answer 9

topically to teat herpes keratitis

Question 10

what are idoxuridine and trifluridine toxic

Answer 10

non-selective so they are systemically toxic

Question 11

what things can imiquimod be used to treat

Answer 11

equine aural plaques, sarcoids, feline-associated papillomavirus

Question 12

remdesivir has been shown to be effective against what

Answer 12

FIP in cats