Antiviral I

Question 1

Host range is determined by?

Answer 1

specific host attachment sites and cellular factors

Question 2

H and N are spikes on the influenza virus. What are the names of said spikes?

Answer 2

Hemagglutinin and Neuraminidase

Question 3

Which of these viruses cross the species barrier?
A. Influenza
B. Coronavirus
C. HIV
D. All of the above

Answer 3

D. All of the above

Question 4

Bacteria are similar to viruses in what way?

Answer 4

In very few ways, they do not have many similarities.

Question 5

Viruses attach to the receptor and enter. What must happen to reveal the RNA or DNA?

Answer 5

Uncoating the envelope

Question 6

How do Ion channel blockers relate to the Influenza virus?

Answer 6

prevent the Acidification of the virion

Question 7

mRNA is transcribed from the ( ) strand

Answer 7

negative ( -) strand

Question 8

mRNA(+) is transcribed from the ( ) strand

Answer 8

negative ( -) strand

Question 9

+ sense RNA are copied in to a () then a () strand.

Answer 9

Into a - strand and then a + strand.

Question 10

+ sense RNA is copied into a () then a () strand.

Answer 10

Into a - strand and then a + strand.

Question 11

Which 2 drugs inhibit viral attachment and entry?

Answer 11

Enfuvirtide (T-20) and Maraviroc

Question 12

Enfuvirtide targets?

Answer 12

Viral Protein

Question 13

Maraviroc targets?

Answer 13

Host protein

Question 14

HIV specific targets are
A. CCR5
B. HIV Integrase
C. HIV gp120
D. CD8
E.  A, B, C
F. A, C, D

Answer 14

E. A, B, and C

Question 15

What does enfuvirtide resemble?

What does it do?

Answer 15

HR1, prevents membrane fusion and viral entry

Question 16

Maraviroc has what mechanism? What can it not bind?
A. CXCR4 and CCLR
B. CD4 and CCR5
C. CCR5 and CD8
D. CCR5 and CXCR4

Answer 16

prevents binding of CCR5 and it cannot bind CXCR4.

Question 17

What two drugs inhibit viral uncoating? (R-AM)

Answer 17

Rimantadine and Amantadine

Question 18

What is the function of the M2 receptor?

Answer 18

allows diffusion of H+ proteins from the H+ATPase/ to trigger acidity and trigger uncoating.

Question 19

Amantadine and Rimantadine block what?

Answer 19

Block M2 ion channels that inhibits the acidity of the the virion and precent uncoating

Question 20

Inhibition of viral (“vir”) release(“Osel” ) is done by which two drugs?

Answer 20

Zanamivir and Oseltamivir

Question 21

What do Zvir and Osel prevent influenza from doing?
A. Entry
B. Attachment
C. Uncoating
D. Release

Answer 21

These drugs interfere with the release of progeny

influenza virus from infected to new host cells.

Question 22

What component of influenza allows for the release of the virion?

Answer 22

N-Acetylneuranimic acid is
cleaved off by the viral
neuraminidase (sialidase) to
facilitate the release of virions from the cell

Question 23

Mutation in neuraminidase results in?
A. Resistance with Oseltamivir
B. Resistance with Enfuvirtide
C. Maraviroc- resistant 
D. Anantadine- resistant

Answer 23

A. Resistance with Oseltamivir