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Antimicrobial > Anti-Protist & Anti-Helminth > Flashcards

Anti-Protist & Anti-Helminth Flashcards

1
Q

Parasites are a complex organism

A

True

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2
Q

Protist one-celled organisms

A

True

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3
Q

Helminths are parasitic worms and are much larger than?

A

Protists

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4
Q

Antiparasitic drugs are not known to be toxic.

A

False

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5
Q

Malara caused by

A. Mosquito
B. P. vivax
C. P. ovale
D. All of the above

A

D. All of the above

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6
Q

The zygote form into an oocyst which will release what?

A

sporozoites

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7
Q

Do sporozoites multiply sexually or asexually?

A

Asexually

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8
Q

Where does the malarial infection take hold?

A

In the liver

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9
Q

What invades the erythrocytes?

A

Merozoites

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10
Q

T or F: P. falciparum causes the blood cells to stick together due to the knobs that grow on their surface

A

True

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11
Q

The drugs act at what stage?

A

Blood schizont

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12
Q

Where do malarial plasmodia get their amino acids from?

A

From the hemoglobin by digesting it

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13
Q

Free Heme is not toxic

A

False

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14
Q

Hemozoin is not toxic

A

True

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15
Q

Quinoline is a natural drug that prevetnts tthe detoxification of toxic free heme. What drugs are like it?

A. Chloroquine
B. Quinine or Quinidine
C. Artemisinin
D. All of the above

A

D. All of the above

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16
Q

The mutation found that a transporter pumps out the chloroquine is found in which disease?

A

Malaria

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17
Q

ACT is ?

A

Artemisinin Combination Therapy, the first line treatment of malaria

18
Q

DHOD performs a key step to make?

A

Pyrimidine synthesis

19
Q

Atovaquone and Primaquine are related to ubiquinone and shuts down?

A

pyrimidine nucleotide biosynthesis, so no DNA or RNA and kills parasite.

20
Q

Doxycycline, and tetracycline, clindamycin are used in?

A

Combination of malarial drugs.

21
Q

Amebiasis are

A

Amebozoas.

Examples: E. histolytica

22
Q

Metronidazole is a prodrug targeting what ?

A

Membranes of parasites

23
Q

Metrodinazole is active by ?

A

Ferrodoxin

24
Q

Metronidazole has been shown some resistance to which organism ?

A

Giardia, parasite found in contaminated food and water.

25
Q

Trypanosomiasis is caused by

A

Trypanosomiasis brucei, a protist.

26
Q

Leishmaniasis is caused by

A

Leishmania. A small bite from a sandfly.

27
Q

Drugs that work against trypanosome and has a high affinity for mtDNA OF THE KINETOPLASTIDS of which blocks it’s DNA replication?

A

Pentamindine

28
Q

Drugs that works against trypanosome that binds the protein and lipids to inhibit metabolism.

A

Suramin

29
Q

Drugs that work against trypanosome inhibits pyruvate kinase which is used in ?

A

Melarsprol and pyruvate kinase is used in glycolysis

30
Q

Drugs that work against trypanosome less toxic alternative to melarsoprol ?

A

Eflornithine

31
Q

Helminth infections are parasitic ______?

A

Worms

32
Q 
River blindness is cause which organism 
A. E. Histolyica 
B. Gardisia 
C. P. Vivax
D. O. volvulus
A

D. O. volvulus

33
Q

What is the most famous anti parasitic drug ?

A

Ivermectin

34
Q

What drug binds to the channels of the nerve and muscle cells ?

A

Ivermectin

35
Q

What drug causes constant open of the channels in the absence of glutamate ?

A

Ivermectin

36
Q

Another drug to treat helminths is called ?

A

Microtubule inhibitors

37
Q

T or F Nematode beta tubulin is similar to human beta tubulin.

A

False, they are sufficiently different.

38
Q

Inhibitors of plasmodia electron transport

A

Atova and prima

39
Q

Which two combo drugs are not used because parasite are resistant to the drug

A

Sulfa and pyrimeethamine

40
Q

Most eukaryotes lack the fermentation enzyme ?

A

PFOR

41
Q

Low resistance in parasites is due to few ____________ alternatives

A

Metabolic

Antimicrobial (8 decks)

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