Antiviral Drugs

Question 1

Name the mechanism, SAEs, and what diseases the drug treats:

Maraviroc

Answer 1

Blocks CCR5 receptor on monocytes and CD4+ T cells to keep HIV from binding to T cells

No listed SAEs

Question 2

Name the mechanism, SAEs, and what diseases the drug treats:

Enfuvirtide

Answer 2

Prevents HIV from fusing with cell membranes.

No listed SAEs

Question 3

Name the mechanism, SAEs, and what diseases the drug treats:

Interferon

Answer 3

Regulates Jak-STAT pathway, inhibits translation and promotes degradation of viral mRNA

Not specific to a virus

SAEs are bone marrow depression and flu-like symptoms

Question 4

Name the mechanism, SAEs, and what diseases the drug treats:

Darunavir

Answer 4

HIV protease inhibitor

SAEs are lipodystrophy and insulin resistance

Question 5

Name the mechanism, SAEs, and what diseases the drug treats:

Ritonavir

Answer 5

HIV protease inhibitor and a strong inhibitor of CYP3A4 so it boots other protease inhibitors.

No listed SAEs

Question 6

Name the mechanism, SAEs, and what diseases the drug treats:

Paritaprevir

Answer 6

Hep C protease inhibitor.

Part of a multi-drug pack called Viekira - specific for Hep C

No listed SAEs

Question 7

Name the mechanism, SAEs, and what diseases the drug treats:

Tenofovir

Answer 7

Nucleoside reverse transcriptase inhibitor

SAEs are hepatotoxicity and lactic acidosis

Question 8

Name the mechanism, SAEs, and what diseases the drug treats:

Sofosbuvir

Answer 8

Hep C RNA polymerase inhibitor

No SAEs listed

Question 9

Name the mechanism, SAEs, and what diseases the drug treats:

Raltegravir

Answer 9

HIV integrase inhibitor

No SAEs listed

Question 10

Name the mechanism, SAEs, and what diseases the drug treats:

Oseltamivir

Answer 10

Influenza neuraminidase inhibitor

No SAEs listed

Question 11

Name the mechanism, SAEs, and what diseases the drug treats:

Ledipasvir

Answer 11

Blocks Hep C NS5A, which is needed for viral RNA synthesis

No SAEs listed

Part of the Viekira pack

Question 12

Name the mechanism, SAEs, and what diseases the drug treats:

Foscarnet

Answer 12

Blocks viral DNA polymerase

Nephrotoxicity

Question 13

Name the mechanism, SAEs, and what diseases the drug treats:

Efavirenz

Answer 13

Non-nucleotide reverse transcriptase inhibitor for HIV Tx

CNS toxicity, skin rashes

Question 14

Name the mechanism, SAEs, and what diseases the drug treats:

Acyclovir

Answer 14

Blocks viral DNA polymerase

No SAEs listed

Question 15

Blocks CCR5 receptor on CD4+ T cells and monocytes

Answer 15

Maraviroc

Question 16

Prevents HIV from fusing with cell membranes.

Answer 16

Enfuvirtide

Question 17

SAEs are bone marrow depression and flu-like symptoms

Answer 17

Interferon

Question 18

SAEs are lipodystrophy and insulin resistance

Answer 18

Darunavir

Question 19

HIV protease inhibitor

Answer 19

2!

Darunavir and Ritonavir

Question 20

Strong inhibitor of CYP3A4 so it boots other protease inhibitors.

Answer 20

Ritonavir

Question 21

Hep C protease inhibitor.

Answer 21

Paritaprevir

Question 22

Nucleoside reverse transcriptase inhibitor

Answer 22

Tenofovir

Question 23

Hep C RNA polymerase inhibitor

Answer 23

Sofosbuvir and ledipasvir

Question 24

HIV integrase inhibitor

Answer 24

Raltegravir

Question 25

Influenza neuraminidase inhibitor

Answer 25

Oseltamivir

Question 26

Blocks Hep C NS5A, which is needed for viral RNA synthesis

Answer 26

Ledipasvir

Question 27

Blocks viral DNA synthesis

Nephrotoxicity

Answer 27

Foscarnet

Question 28

Non-nucleotide reverse transcriptase inhibitor for HIV Tx

Answer 28

Efavirenz

Question 29

Blocks viral DNA polymerase

Answer 29

Acyclovir

Question 30

SAEs are hepatotoxicity and lactic acidosis

Answer 30

Tenofovir