Anti-Parasitic Drugs Flashcards
1
Q
Metronidazole
A
Forms intermediates that destroy protozoal DNA.
Headache, peripheral neuropathy, alcohol sensitivity
2
Q
Chloroquine
A
Prevents heme polymerization to hemozoin
GI distress, skin rash, headaches
3
Q
Artemisinins
A
Metabolized to toxic free radicals.
GI distress
4
Q
Quinine
A
Maybe toxic free radicals (unknown)
GI distress, headache, vertigo, blurred vision
5
Q
Atovaquone
A
Disrupts electron transport chain.
GI distress
6
Q
Pyrimethamine
A
Inhibits protozoal DHF reductase
7
Q
Albendazole
A
Prevents microtubule assembly
Leukopenia w/ prolonged use
8
Q
Ivermectin
A
Increases GABA –> immobilization of worm
SAEs are reactions to dying worms
9
Q
Mebendazole
A
Inhibits microtubule synthesis
GI distress
10
Q
Praziquantel
A
Increases membrane permeability to calcium –> paralysis
