Antiseizure meds Flashcards
Features of grand mal seizure
loss of postural control
LOC
abnormal behavior, confusion
EEG = high amplitude
Features of petit mal seizure
normal muscle tone
transient LOC
normal fxn after
EEG = 3 Hz
grand mal seizure propag via
1) decr GABA tone
2) incr response to glutamate
3) incr Na+ channel conduction
must block Na+ channels in use dependent manner (when no seizure, no effect of drug)
petit mal seizure generated by
activation of low threshold T type Ca2+ channel
oscillatory stim of thalamic and cortical neurons
1 drug for general absence in higher doses long term
valproic acid
1 drug for partial seizure alternative for general
carbamazepine
1 for general absence seizure
ethosuximide
Gabapentin
useful in what seizure types
MOA
DON’T NEED
treating partial seizures +/- secondary generalization
incr brain GABA possibly via inhib GABA-T
Vigabatrin
MOA
DON’T NEED
suicide inactiv of GABA transaminase
control of complex partial + grand mal
aggravate absence
Felbamate
MOA
DON’T NEED
incr seizure threshold + prevent spread
inhib NMDA glutamate
drugs used for grand mal tonic clonic
rank in order
valproate
lamotrigine
levetiarcetam
drugs used for absence
rank in order
ethosuximide
valproate
drugs used for partial
rank in order
carbamazepine
lamotrigine
levetiracetam
drugs used for status epilepticus
rank in order
Benzodiazepine
diazepam-lorazepam-midazolam
