antiseizure drugs + antiepileptics Flashcards
seizure
the clinical manifestation of an abnormal and excessive excitation and synchronization of population of cortical neurons
pathophysiology
excessive and abnormal nerve cell activity in the cortex of the brain
increased glut transmission
decrease in GABA
increase membrane excitability
epilepsy
tendency towards recurrent seizures
unprovoked by any systemic or acute neurologic insul
epileptogenesis
sequence of events that convert a normal neuronal network into a hyperexcitable network
partial seizures
simple; no disturbance of consciousness
complex; disturbance of consciousness
generalized seizure
- grand mal seizure; tonic-clonic
- petit mal; absence
- myoclonic
- atonic
- status epilepticus
- lennox-gastaut syndrome
site of action antiseizure drugs
- inhibition of excitatory, glutamate, activity
- enhancement of inhibitory, GABA, activity
Na channel blockers
phenytoin
carbamazepine
valproate
lamogtrigine
topiramate
GABA mimetics
phenobarbital
tiagabine
vigabatrine
Ca channel blocker
gabapentin, pregabalin
levetiracetam
ethosuximide
BZD
clonazepam
clobasam
diazepam
