antidepressants Flashcards

1
Q

symptoms

A
  • persistent sadness / depressed mood
  • loss of interest or pleasure
  • fatigue and low energy
    needs to be consistent for 2 weeks
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2
Q

types of depression

A
  • psychotic depression
  • seasonal depression
  • perinatal, postpartum, menopausal depression
  • bipolar or maniac depression
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3
Q

neurotrophic hypothesis

A

atrophy of neurons, loss of neurotrophic support
antidepressants will increase BDNF, but takes a long time
loss of hippocampus

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4
Q

monoamine hypothesis

A

low level of monoamine neurotransmitters; serotonin, noradrenaline and dopamine in the synapse
most drugs will inhibit reuptake mechanism
quick effect, but long time until therapeutic effect

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5
Q

neuroendocrine factors

A

associated with hormonal abnormalities
elevated cortisol levels, elevated levels of corticotropin-releasing hormone

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6
Q

types of antidepressants

A

uptake inhibitors;
- TCA
- SSRI
- SNRI
- NRI
- NDRI
- SARI
MAO inhibitors
presynaptic receptor blocker

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7
Q

TCA

A

inhibition of NET and SERT
imipramine
clomipramine
amitriptyline

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8
Q

SSRIs

A

selective serotonin reuptake inhibitors
SSS side effect; stomach, serotonin syndrome, sexual disfunction
fluoxetine
fluvoxamine
citalopram
escitalopram
paroxetine

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9
Q

SNRIs

A

serotonin and noradrenaline reuptake inhibitors
venlafaxine
duloxetine

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10
Q

NDRI

A

noradrenaline-dopamine reuptake inhibitor
bupropion

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11
Q

SARI

A

serotonin antagonist and reuptake inhibitor
trazodone

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12
Q

MAO inhibitors

A

inhibit degradation of monoamine
cheese effect
moclobemide (MAO-A)
selegiline, rasagiline (MAO-B)

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13
Q

NaSSA

A

presynaptic receptor blocker
noradrenergic and specific serotonergic antidepressants
mirtazapine
mianserine

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