anxiety and sleep disorders Flashcards
anxiolytic effect
reduction of anxiety without influencing motor or mental functions
sedative effect
suppression of responsiveness to a constant level of stimulation with decreased spontaneous activity and ideation
hypnotic effect
producing drowsiness, promoting the onset and maintenance of a state of sleep that as far as possible resembles the natural sleep state
insomnia
sleeping disorder
hard to fall and stay asleep
feel tired when waking up
GABA modulators
barbituric acid
MOA of barbiturates facilitates the actions of GABA by increasing the duration of the GABA-gated channel openings, effect will be enhanced
thalidomid
sedative and hypnotic effect
no antibiotic effect
withdrawn
benzodiazepine
1st choice
lorazepam
binding site at the GABAa receptor, BDZ receptor. promote the GABA binding to its own binding site.
inhibitory, increasing the frequency of Cl-channel opening
BZD receptor ligands
agonists; diazepam
antagonist; flumazenil
anxiolytic treatment
sedative
medazepam
clobazam
tofisopam
hypnotic treatment
brotizolam
cinolazepam
non-GABAergic anxiolytics
serotonergic drugs
SSRI
buspiron
non-GABAergic hypnotics
ramelteon
tasimelteon
suvorexant
drugs in anxiety
benzodiazepines
antidepressants; SSRI
buspirone
therapy of insomnia
z-drugs
