Antipsych Flashcards
First synthetic drug to block dopamine transmission
chlorpromazine
perphenazine
typical antipsychotic D2 blocker
Reserepine side effects
hypotension, especially orthostatic hypotension
trifluoperazine
typical antipsychotic D2 blocker
thioridazine
typical antipsychotic D2 blocker
Hypotheses of schizophrenia
- serotonin-certain drugs such as LSD
- dopamine-too much dopamine
- glutamate-over excitation
First drugs to be used to treat schizo
Reserpine (plant)
Chlorpromazine (synthetic)
chlorpromazine
antiemetic .. D2 blocker .. typical antipsychotic
Typical antipsychotic are derivatives of
phenothiazine
fluphenazine
typical antipsychotic D2 blocker (very emetogenic)
Typical anti psychs thioxanthene derivatives
thiotixene-block D2
typical antipsychotic thioxanthene derivatives
haloperidol -block D2
Reserepine side effects of orthostatic hypotension occur due to
blockade of alpha adrenoreceptor
Regarding antipsychotic drugs, loss of accommodation, dry mouth, difficulty urinating and constipation occur due to
muscarinic cholinoceptor blockade
Amenorrhea, galactorrhea, infertility, impotence occur due to
dopamine -recetor blockade resulting in hyperprolactinemia
Weigh gain due to
possible combined blockade of H1 and 5-HT2 blockade
Typical antipsychotics have increased side effects due to
b/c they react with other receptors other than D2
Chlorpromazine
blocks D2 one of the first drugs used (antiemetic)
Thioridazine
blocks D2 -phenothiazine derivative
Trifluoperazine
blocks D2 -phenothiazine derivative
Haloperiodol
blocks D2 -butyrophenone derivative (modified compared to old class, but still typical.
Clozapine
atypical antipsychotic. Works with serotonin receptors , not D2.
Olanzapine
atypical antipsychotic. Works with serotonin receptors , not D2.
Quetiapine
atypical antipsychotic. Works with serotonin receptors , not D2.
Risperidone
atypical antipsychotic. Works with serotonin receptors , not D2.
LIthium carbonate
lowers DAG and Ip3
