Antipsych

Question 1

First synthetic drug to block dopamine transmission

Answer 1

chlorpromazine

Question 2

perphenazine

Answer 2

typical antipsychotic D2 blocker

Question 3

Reserepine side effects

Answer 3

hypotension, especially orthostatic hypotension

Question 4

trifluoperazine

Answer 4

typical antipsychotic D2 blocker

Question 5

thioridazine

Answer 5

typical antipsychotic D2 blocker

Question 6

Hypotheses of schizophrenia

Answer 6

1. serotonin-certain drugs such as LSD
2. dopamine-too much dopamine
3. glutamate-over excitation

Question 7

First drugs to be used to treat schizo

Answer 7

Reserpine (plant)

Chlorpromazine (synthetic)

Question 8

chlorpromazine

Answer 8

antiemetic .. D2 blocker .. typical antipsychotic

Question 9

Typical antipsychotic are derivatives of

Answer 9

phenothiazine

Question 10

fluphenazine

Answer 10

typical antipsychotic D2 blocker (very emetogenic)

Question 11

Typical anti psychs thioxanthene derivatives

Answer 11

thiotixene-block D2

Question 12

typical antipsychotic thioxanthene derivatives

Answer 12

haloperidol -block D2

Question 13

Reserepine side effects of orthostatic hypotension occur due to

Answer 13

blockade of alpha adrenoreceptor

Question 14

Regarding antipsychotic drugs, loss of accommodation, dry mouth, difficulty urinating and constipation occur due to

Answer 14

muscarinic cholinoceptor blockade

Question 15

Amenorrhea, galactorrhea, infertility, impotence occur due to

Answer 15

dopamine -recetor blockade resulting in hyperprolactinemia

Question 16

Weigh gain due to

Answer 16

possible combined blockade of H1 and 5-HT2 blockade

Question 17

Typical antipsychotics have increased side effects due to

Answer 17

b/c they react with other receptors other than D2

Question 18

Chlorpromazine

Answer 18

blocks D2 one of the first drugs used (antiemetic)

Question 19

Thioridazine

Answer 19

blocks D2 -phenothiazine derivative

Question 20

Trifluoperazine

Answer 20

blocks D2 -phenothiazine derivative

Question 21

Haloperiodol

Answer 21

blocks D2 -butyrophenone derivative (modified compared to old class, but still typical.

Question 22

Clozapine

Answer 22

atypical antipsychotic. Works with serotonin receptors , not D2.

Question 23

Olanzapine

Answer 23

atypical antipsychotic. Works with serotonin receptors , not D2.

Question 24

Quetiapine

Answer 24

atypical antipsychotic. Works with serotonin receptors , not D2.

Question 25

Risperidone

Answer 25

atypical antipsychotic. Works with serotonin receptors , not D2.

Question 26

LIthium carbonate

Answer 26

lowers DAG and Ip3