Antiprotozoans

Question 1

What is Amebiasis caused by?

Answer 1

Entamoeba histolytica

Question 2

What are the symptoms of Amebiasis?

Answer 2

Diarrhea
Abdominal Pain
Weight loss

Question 3

What drugs are used to treat Amebiasis?

Answer 3

Iodoquinol
Paromomycin
Metronidazole
Tinidazole

Question 4

What is the MOA of Iodoquinol?

Answer 4

chelates iron needed for aembia

Question 5

What are the ADRs of Iodoquinol?

Answer 5

Rash
Acne
Thyroid Enlargement
Nausea/Vomiting
Diarrhea
Vision Loss

Question 6

What is the MOA of Paromomycin?

Answer 6

Irreversibly binds to 30S ribosomal subunit and inhibits protein synthesis

Question 7

What is Paromomycin?

Answer 7

Aminoglycoside

Question 8

What are the ADRs of Paromomycin?

Answer 8

Nausea
Cramps
Diarrhea

Question 9

What is the MOA of Tinidazole?

Answer 9

interact with DNA to cause strand breakage

Question 10

What are the ADRs of Tinidazole?

Answer 10

metallic taste
Stomatitis
Dyspepsia
Peripheral Neuropathy

Question 11

What must you dose adjust for with Tinidazole?

Answer 11

liver

Question 12

What is Cryptosporidiosis caused by?

Answer 12

Cryptosporidium parvum

Question 13

What are the symptoms of Cryptosporidiosis?

Answer 13

Diarrhea
Abdominal Cramps
Anorexia
Low-grade fever
Nausea
Vomiting

Question 14

What drug is used to treat Cryptopsoridiosis?

Answer 14

Nitazoxanidine

Question 15

What is the MOA of Nitazoxanide?

Answer 15

Disrupting protozoal energy metabolism by blocking electron transfer mediated by pyruvate ferredoxin oxidoreductase

Question 16

What are the ADRs of Nitazoxanide?

Answer 16

Abdominal pain
Diarrhea
Vomiting
Headache
Yellowing of the eyes

Question 17

What must you dose adjust for with Nitazoxanide?

Answer 17

liver

Question 18

What is Giardiasis caused by?

Answer 18

Giardia Lamblia

Question 19

What spreads Giardia Lamblia?

Answer 19

contaminated drinking water

Question 20

What are the symptoms of Giardiasis?

Answer 20

Malaise
heartburn
Vomiting
Colicky pain after eating
Belching
Flatulence
Diarrhea

Question 21

Where does Giardiasis effect?

Answer 21

the small intestine

Question 22

What are the drugs used to treat Giardiasis?

Answer 22

Metronidazole
Tinidazole
Nitazoxanide

Question 23

What is used to treat Leishmaniasis?

Answer 23

Sodium Stibugluconate

Question 24

What are the ADRs of Sodium Stibugluconate?

Answer 24

Muscle Pain
Joint Stiffness
Bradycardia

Question 25

What must you monitor with Sodium Stibugluconate?

Answer 25

ECG | HR

Question 26

What is toxoplasmosis caused by?

Answer 26

Toxoplasma gondii

Question 27

How is the toxoplasmosis infection acquired?

Answer 27

through eating undercooked meat

Question 28

What symptoms can you get from toxoplasmosis if you are immunocompromised?

Answer 28

Retina and encephalitis

Question 29

What symptoms can you get from toxoplasmosis if you are immunocompetent?

Answer 29

Asymptomatic

Question 30

What drugs do you use to treat toxoplasmosis?

Answer 30

Pyrimethamine Sulfadiazine Clindamycin Atovaquone

Question 31

What is the MOA of Pyrimethamine?

Answer 31

Folic acid antagonist

Question 32

What are the ADRs of Pyrimethamine?

Answer 32

Nausea/Vomiting Glossitis Bone Marrow Suppression

Question 33

What patients should you avoid using Pyrimethamine in?

Answer 33

those with anemia due to folic acid deficiency

Question 34

What should you monitor with Pyrimethamine?

Answer 34

CBC

Question 35

What do you dose adjust for with Pyrimethamine?

Answer 35

Renal

Question 36

What is the MOA of Sulfadiazine?

Answer 36

inhibits dihydropteroate synthase which inhibits the production of folic acid, necessary to make DNA

Question 37

What are the ADRs of Sulfadiazine?

Answer 37

Nausea/Vomiting

Question 38

What must you dose adjust for with Sulfadiazine?

Answer 38

Renal

Question 39

What is Trichomoniasis caused by?

Answer 39

Trichomonas Vaginalis

Question 40

What are the drugs of choice to treat Trichomoniasis?

Answer 40

Metronidazole | Tinidazole

Question 41

What are the ADRs of Nifurtimox?

Answer 41

``` Nausea/Vomiting Peripheral Neuropathy Weight loss Memory loss Insomnia Vertigo Headache ```

Question 42

What must you monitor with Nifurtimox?

Answer 42

WEight

Question 43

What must you adjust for with Nifurtimox?

Answer 43

Liver

Question 44

What is the MOA of pentamidine?

Answer 44

disrupting synthesis of DNA, RNA, and Phospholipids

Question 45

What are the ADRs of Pentamidine?

Answer 45

``` Hypotension Hypo/Hyperglycemia Necrosis at site of IM injection Leukopenia AKI Dysrhythmias ```

Question 46

What must you monitor with Pentamidine?

Answer 46

SCr BUN CBC

Question 47

What must you dose adjust for with Pentamidine?

Answer 47

Renal

Question 48

What is the MOA of Suramin?

Answer 48

inhibit enzymes

Question 49

What are the ADRs of Suramin?

Answer 49

``` Vomiting Itching Rash Parasthesias Photophobia AKI ```

Question 50

What must you monitor with Suramin?

Answer 50

SCr | BUN

Question 51

What must you dose adjust for with Suramin?

Answer 51

Renal

Question 52

What is the MOA of Melarsoprol?

Answer 52

Inactivation of enzymes inside the parasite

Question 53

What are the ADRs of Melarsoprol?

Answer 53

Hypertension Albuminuria Peripheral Neuropathy Myocardial damage

Question 54

What must you dose adjust for with Melarsoprol?

Answer 54

Liver

Question 55

What is the MOA of Eflornithine?

Answer 55

irreversible inhibition of ornithine decarboxylase

Question 56

What are the ADRs of Eflornithine?

Answer 56

``` Anemia Leukopenia Diarrhea Seizures Hair Loss ```

Question 57

What must you dose adjust for with Eflornithine?

Answer 57

Renal