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Clinical Pharmacology II > Antibiotic ADRs > Flashcards

Antibiotic ADRs Flashcards

1
Q

Penicillin ADRs

A 
RASH/HIVES
Nausea
GI upset
anaphylaxis
high salt content
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2
Q

Aminopenicillins

A 
RASH/HIVES
EOSINOPHILIA
Nausea
GI upset
anaphylaxis
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3
Q

Penicillinase resistant penicillins

A 
EOSINOPHILIA
RASH/HIVES
Nausea
GI upset
Anaphylaxis
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4
Q

Aminopenicillins/betalactamase inhibitors

A 
AKI
nausea
GI upset
RASH/HIVES
anaphylaxis
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5
Q

ADR of Ticarrilin

A

bleeding risk

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6
Q

Antipseudomonal penicillins/betalactamase inhibitors

A 
AKI
nausea
GI upset
RASH/HIVES
anaphylaxis
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7
Q

Antipseudomonal Penicillins

A 
Nausea
GI upset
RASH/HIVES
Anaphylaxis
High salt content
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8
Q

1st Gen Cephs

A 
POSITIVE COOMBS TEST
Nausea
GI upset
Rash/Hives
Anaphylaxis
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9
Q

2nd Gen Cephs

A 
INCREASED LFTS
POSITIVE COOMBS TEST
Nausea
GI upset
Rash/Hives
Anaphylaxis
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10
Q

3rd gen cephs

A 
INCREASED LFTS
POSITIVE COOMBS TEST
Nausea
GI upset
Rash/Hives
Anaphylaxis
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11
Q

4th gen cephs

A 
NEUROTOXICITY
Nausea
GI upset
Rash/Hives
Anaphylaxis
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12
Q

5th Gen cephs

A 
NEUROTOXICITY
Nausea
GI upset
Rash/Hives
Anaphylaxis
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13
Q

Ceph/betalactamase inhibitors

A 
ACUTE KIDNEY INJURY
Nausea
GI upset
Rash/Hives
Anaphylaxis
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14
Q

Carbapanems

A 
DECREASES SEIZURE THRESHOLD
Nausea
GI upset
Rash/Hives
Anaphylaxis
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15
Q

Monobactams

A

INCREASED LFTs
Nausea
GI upset
SUPER EXPENSIVE

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16
Q

Glycopeptides

A

ACUTE KIDNEY INJURY
Nausea
THROMBOCYTOPENIA
INFUSION RELATED REACTION

17
Q

Tetracyclines

A

HEPATOTOXICITY
PHOTOSENSITIVTY
ENAMEL AGENESIS

18
Q

Which tetracyclines have vestibular toxicity as an ADR?

A

Doxycycline

Tetracycline

19
Q

Fluoroquinolones

A 
TENDONOPATHIES (BBW)
HYPOGLYCEMIA/HYPERGLYCEMIA
CAUSES DELIRIUM IN ELDERLY
Qtc prolongation
decreased seizure threshold
exacerbated muscle weakness in patients with myasthenia gravis
20
Q

Macrolides

A

Qtc prolongation
Nausea
GI upset

21
Q

Which macrolides are CYP inhibitors?

A

Erythromycin

Clarithromycin

22
Q

Clindamycin

A

take with food due to GI upset
nausea
C. diff infections

23
Q

Metronidazole

A

PERIPHERAL NEUROPATHY if used for more than 2 weeks
GI intolerance
metallic taste
DO NOT TAKE WITH ALCOHOL

24
Q

Bactrim

A 
HYPERKALEMIA
INCREASE SCr
ACUTE KIDNEY INJURY
PHOTOSENSITIVITY
Steven Jorens Syndrome
Toxic Epidermal Necrotitis
25
Q

Aminoglycosides

A

AKI

Ototoxicity

26
Q

Nitrofurantoin

A

Hepatotoxicity
pulmonary toxicity
neuropathy

27
Q

Oxazolidinones

A

thrombocytopenia

Serotonin syndrome if taken with SSRIs, TCAs, or MAOIs

28
Q

Daptomycin

A

Myalgia
Increased CPK
Rhabdomyolysis

29
Q

Streptogramin

A

Myalgia
Arthralgia
Hyperbilirubinemia

30
Q

Rifampin

A 
Myalgia
Arthralgia
Hyperbilirubinemia
CYP inducer
Increases clearance of many drugs
Changes urine, tears, and saliva orange color
31
Q

Fidaxomycin

A

Abdominal pain
Nausea
VERY EXPENSIVE

32
Q

Fosfomycin

A

Diarrhea
headache
liver damage

Clinical Pharmacology II (25 decks)

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