Antibiotic ADRs Flashcards
Penicillin ADRs
RASH/HIVES Nausea GI upset anaphylaxis high salt content
Aminopenicillins
RASH/HIVES EOSINOPHILIA Nausea GI upset anaphylaxis
Penicillinase resistant penicillins
EOSINOPHILIA RASH/HIVES Nausea GI upset Anaphylaxis
Aminopenicillins/betalactamase inhibitors
AKI nausea GI upset RASH/HIVES anaphylaxis
ADR of Ticarrilin
bleeding risk
Antipseudomonal penicillins/betalactamase inhibitors
AKI nausea GI upset RASH/HIVES anaphylaxis
Antipseudomonal Penicillins
Nausea GI upset RASH/HIVES Anaphylaxis High salt content
1st Gen Cephs
POSITIVE COOMBS TEST Nausea GI upset Rash/Hives Anaphylaxis
2nd Gen Cephs
INCREASED LFTS POSITIVE COOMBS TEST Nausea GI upset Rash/Hives Anaphylaxis
3rd gen cephs
INCREASED LFTS POSITIVE COOMBS TEST Nausea GI upset Rash/Hives Anaphylaxis
4th gen cephs
NEUROTOXICITY Nausea GI upset Rash/Hives Anaphylaxis
5th Gen cephs
NEUROTOXICITY Nausea GI upset Rash/Hives Anaphylaxis
Ceph/betalactamase inhibitors
ACUTE KIDNEY INJURY Nausea GI upset Rash/Hives Anaphylaxis
Carbapanems
DECREASES SEIZURE THRESHOLD Nausea GI upset Rash/Hives Anaphylaxis
Monobactams
INCREASED LFTs
Nausea
GI upset
SUPER EXPENSIVE
Glycopeptides
ACUTE KIDNEY INJURY
Nausea
THROMBOCYTOPENIA
INFUSION RELATED REACTION
Tetracyclines
HEPATOTOXICITY
PHOTOSENSITIVTY
ENAMEL AGENESIS
Which tetracyclines have vestibular toxicity as an ADR?
Doxycycline
Tetracycline
Fluoroquinolones
TENDONOPATHIES (BBW) HYPOGLYCEMIA/HYPERGLYCEMIA CAUSES DELIRIUM IN ELDERLY Qtc prolongation decreased seizure threshold exacerbated muscle weakness in patients with myasthenia gravis
Macrolides
Qtc prolongation
Nausea
GI upset
Which macrolides are CYP inhibitors?
Erythromycin
Clarithromycin
Clindamycin
take with food due to GI upset
nausea
C. diff infections
Metronidazole
PERIPHERAL NEUROPATHY if used for more than 2 weeks
GI intolerance
metallic taste
DO NOT TAKE WITH ALCOHOL
Bactrim
HYPERKALEMIA INCREASE SCr ACUTE KIDNEY INJURY PHOTOSENSITIVITY Steven Jorens Syndrome Toxic Epidermal Necrotitis
