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Clinical Pharmacology II > Antibiotic MOA > Flashcards

Antibiotic MOA Flashcards

1
Q

Penicillins

A

Inhibits penicillin binding protein directly

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2
Q

Aminopenicillins

A

added side chains to increase the selectivity to Inhibit penicillin binding protein directly

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3
Q

Penicillinase Resistant Penicillins

A

Avoids binding with penicillinase/betalactamase so that it can still bind to the penicillin binding protein and inhibit it

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4
Q

Aminopenicillins/Betalactamse inhibitor

A

binds to betalactamase and penicillin binding protein and directly inhibits both

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5
Q

Antipseudomonal penicillins/betalactamase inhibitors

A

binds to betalacatmase and penicillin binding protein and directly inhibits both

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6
Q

Antipseudomonal penicillins

A

directly inhibits penicillin binding protein

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7
Q

1st gen cephs

A

Directly inhibits PBP

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8
Q

2nd gen cephs

A

Directly inhibits PBP

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9
Q

3rd gen cephs

A

Directly inhibits PBP

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10
Q

4th gen cephs

A

Directly inhibits PBP

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11
Q

5th gen cephs

A

Directly inhibits PBP

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12
Q

ceph/betalactamase inhibitors

A

Directly inhibits PBP

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13
Q

Carbapanems

A

Directly inhibits PBP

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14
Q

Monobactams

A

Directly inhibits PBP

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15
Q

Glycopeptides

A

indirectly inhibits PBP from crosslinking peptidoglycan by sitting on the side chains of bacteria

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16
Q

Tetracyclines

A

inhibits protein synthesis; 30s ribosomal subunit

17
Q

Fluoroquinolones

A

inhibits both DNA gyrase and topoisomerase IV and prevents bacteria from replicating DNA

18
Q

Macrolides

A

inhibits protein synthesis; 50S ribosomal subunit

19
Q

Clindamycin

A

inhibits protein synthesis; 50S ribosomal subunit

20
Q

Metronidazole

A

inhibits DNA synthesis by causing strand breakage

21
Q

Bactrim

A

inhibits formulation of nucleic acids needed for DNA synthesis/replication

22
Q

Aminoglycosides

A

Irreversibly binds with 30S ribosomal subunit causing the mRNA to be misread

23
Q

Nitrofurantoin

A

metabolized within the bacterial cell to reactive intermediates that destroy ribosomal proteins

24
Q

Oxazolidinones

A

inhibits protein synthesis; 50S ribosomal subunit

25
Q

Daptomycin

A

binds with calcium and inserts itself into the phospholipid cytoplasmic membrane; other molecules aggregate and create holes in the membrane; this causes efflux of potassium and kills the bacteria

26
Q

streptogrammin

A

Inhibits protein synthesis; 50s ribosomal subunit

27
Q

Rifampin

A

Inhibits RNA polymerase; prevents RNA production

28
Q

Fidaxomycin

A

Binds to RNA polymerase and doesn’t allow DNA to enter and transcription does not occur

29
Q

Fosfomycin

A

inhibits enzyme MurA; causes death by inhibiting cell wall synthesis

Clinical Pharmacology II (25 decks)

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