Antipllatelets/Anticoagulents Flashcards
1
Q
Warfarin (Coumadin)
A
Inhibits vitamin K in its role in clot formation. Vitamin K antagonist (i.e. outcompetes vitamin K in binding in clotting cascade).
Anticoagulant
2
Q
Heparin
A
- Prevents fibrin formation
- Accelerates inactivation of coagulation factors by antithrombin
Anticoagulant
3
Q
Low-Molecular Weight Heparin
A
Selectively accelerates interaction of antithrombin and clotting factor Xa
Anticoagulant
4
Q
Dabigatran (Pradaxa)
A
Direct thrombin inhibitor
Anticoagulant
5
Q
Clopidogrel (Plavix)
A
Inhibits platelets ability to adhere to fibrinogen and each other. (ADP receptor inhibitor)
Anti-platelet
6
Q
Ticlopidine (Ticlid)
A
Inhibits platelet ability to adhere to fibrinogen and each other (ADP receptor inhibitor)
Anti-platelet
7
Q
Dipyridamle (persantine)
A
Decreases platelet “stickiness” and therefore ability to adhere to thrombogenic surfaces
8
Q
Asprin (ASA)
A
- ASA changed to salicylic acid which has anti-inflammatory, antipyretic and analgesic effects.
- Blocks prostoglandin synthesis.
