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Pharm > Antineoplastics > Flashcards

Antineoplastics Flashcards

1
Q

Leading cause of cancer in men and women

A

1st lung

2nd colorectal

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2
Q

How can tumors spread

A

Lymp
Blood
Body spaces
Implantation

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3
Q

Chemotherapy

A

Alkylating agents, antimetabolites, plant alkaloids, anti tumor antibiotics, hormones

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4
Q

Alkylating agents

A

Inhibit DNA replication
Cell cycle non-specific

Nitrogen mustards, platinum analogs, notrosoureas, alkyl sulfonates, non classic

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5
Q

Nitrogen mustards

A

Cyclophosphamide

Chlorambucil

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6
Q

Platinum agents

A

Cisplatin
Carboplatin
Oxaliplatin

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7
Q

Nitrosoureas

A

Carmustine

Lomistine

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8
Q

Non classic

A

Dacarbazine

Procarbazine

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9
Q

Antimetabolites

A

S phase
DNA rna synthesis
Replication and cell division

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10
Q

Antimetabolites

A

5-fluorouracil

Methotrexate

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11
Q

5-fluorouracil

Methotrexate

A

Mucositis

Taste alterations

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12
Q

Plant alkaliods

A

M phase
Leads to cell
Death

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13
Q

Plant alkaloids

A

Vincristine
Vinblastine
Docetaxel

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14
Q

Antitumor Antibiotics

A

Cell cycle non specific
Blocks dna rna synthesis, interferes with cel replication

Toxicities
Myelosuppression
Mucositis
Reproductive
Cardiac
GI
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15
Q

Antitumor Antjbiotics

A

Bleomycin
Doxorubicin
Mitomycin

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16
Q

Hormones

A

Estrogen receptor modulators
Aromatase inhibitors
Antiandrogens

17
Q

Estrogen receptor modulators

A

Bind to estrogen receptor decreasing dna synthesis

Tamoxifen

18
Q

Aromatase inhibitors

A

Used after tamoxifen

Anstrozole
Letrozole
Exemestane

19
Q

Anti androgens

A

Prostate cancer

Bicalutamide
Flutamide

20
Q

Biological response modifier

A

Inhibits replication, suppresses proliferation, enhances cell breakdown

Side effects use to increase capillary permeability

21
Q

Biological Response Modifiers

A

Interferon

Rituximab

22
Q

Bone metabolism

Regulators

A

Inhibits bone resorption

Binds to crystals in bone matrix, inhibits osteoclasts function

23
Q

Bone metabolism regulator

A

Pamidronate
Clodronate
osteonecrosis of jaw

24
Q

Mucositis

A

Mouth sores on soft tissues and tongue
Shiny, swollen, red, white patches
Painful slow healing

25
Q

Mucositis prevention/treatment

A

Ice chips, oral hygiene, alcohol free mouthwashes

Acetaminophen, oral saline rinse, avoid irritations, remove dentures

26
Q

Candidiasis treatment

A

Nystatin

Fluconazole

Pharm (9 decks)

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