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Pharm > Adrenocorticosteriods > Flashcards

Adrenocorticosteriods Flashcards

1
Q

Adrenocortiocosteroid

A

Corticosteroid or steroids

Glucocorticoid and mineralcorticoid

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2
Q

Glucocorticoid

A

Affects carbohydrate metabolism

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3
Q

Mineralocorticoid

A

Affects body’s sodium and water balance

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4
Q

ACTH

A

Adrenocorticotropic hormone
Secreted by pituitary gland
Causes hormone release from adrenal cortex

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5
Q

Addison disease

A

Deficiency of adrenocorticosteroids

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6
Q

Cushing syndrome

A

Caused by excess of adrenocorticosteriods

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7
Q

Adrenocorticosteroids

A 
Naturally occurring 
Used therapeutically (oral lesions)
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8
Q

Mechanism of release

A

Hormone secreted by adrenal cortex
Hypothalamus releases corticotepin releasing hormone CRH
CRH acts of pituitary gland
Pituitary gland releases ACTH
ACTH stimulates adrenal cortex to release hydrocortisone
Hydrocortisone acts on pituitary gland and hypothalamus to inhibit release of CRH and ACTH
(Negative feedback system)

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9
Q

Hydrocortisone

A

Life sustaining hormone
Maintenance of homeostasis
Regulates blood sugar, carb metabolism, fat, protein, immune response, anti inflammatory, bp

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10
Q

Exogenous corticosteroids

A

Act in the same way as hydrocortisone (inhibit CRH and ACTH release)
Long term admin will cause ACTH suppression
Body cannot quickly respond to stress

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11
Q

Adrenal crisis

A

Weakness, drop in bp, loss of consciousness, cardiovascular collapse, death

(Supplement the amount of exogenous corticosteroids to prevent adrenal crisis)

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12
Q

Glucocorticoid mechanism of action

A

Steroid binds to receptor and forms a complex

Complex moves into cells and affects cell processes (inflammation, immune response)

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13
Q

Exogenous glucocorticoid pharmacological effect

A

Anti inflammatory
Suppression of allergic reactions
Suppression of immune response
Pallative not curative

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14
Q

Exogenous glucocorticoid route of administration

A

Topical
Inhalation
Oral
Injection

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15
Q

Exogenous glucocorticoid adverse reactions

A 
Cushing syndrome appearance 
Hyperglycemia
Cns
Ophthalmic
Peptic ulcer
Electrolyte and fluid balance
Infection
Imputed wound healing 
Osteoporosis
Adrenal crisis
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16
Q

Adrenal suppression

A

Higher dose, longer duration, greater potency, quicker suppression
Can take weeks or months to respond normally

17
Q

Exogenous glucocorticoid dental effects

A

Delayed healing of mucosal surfaces
Decrease resistance to infection
Oral candidiasis

18
Q

Exogenous glucocorticoid medical uses

A

Inflammation/allergy (topical for skin conditions)
Emergencies (treat of shock or adrenal crisis)
Replacement therapy (Addison disease)

19
Q

Exogenous glucocorticoid dental uses

A 
Oral lesions
Aphthous stomatitis
Tmj pain
Oral surgery
Pulp procedures
20
Q

Management of dental patient

A

Intermediate doses my require additional corticosteroids of procedure is likely to cause severe stress

Pharm (9 decks)

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