Antimicrobials: Selective Toxicity Flashcards
1
Q
Prototypical Penicillins
A
Humans don’t have cell walls
2
Q
Cephalosporins: Penicillinase resistant
A
Humans don’t have cell walls
3
Q
Carbapenems. Beta lactamase resistant.
A
Humans don’t have cell walls
4
Q
Monobactams
A
Humans don’t have cell walls
5
Q
Vancomycin
A
Humans don’t have cell walls
6
Q
Macrolides
A
Humans don’t have 50S
7
Q
Tetracylines
A
Humans don’t have 30S
8
Q
Metronidazole
A
Active on organisms performing anaerobic respiration
9
Q
Fluoroquinolones
A
Humans don’t have DNA gyrase, we supercoil in other ways
10
Q
Sulfonamides
A
Humans get Folic Acid from diet, don’t have to synthesize it for DNA. Also, humans lack DHPS enzyme
11
Q
Nitrofurantoin
A
Mamillian enzymes don’t reduce it as rapidly
12
Q
Antituberculuar Agents (Rifampin)
A
Bacteria have different RNA polymerase
