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Infectious Disease: Unit 1 > Antimicrobials: MOA > Flashcards

Antimicrobials: MOA Flashcards

1
Q

Bactericidal antibiotics

A

penicillins
cephalosporins
vancomycin
aminoglycosides
fluroquinolones
rifampin
polymyxins, daptomycin

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2
Q

Prototypical Penicillins (All penicillins): MOA

A

Stage 3 Cell Wall Synthesis: PG cross-linking, bacteriocidal

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3
Q

Penicillinase Resistant Penicillins

A
  • Stage 3 Cell Wall Synthesis: PG cross-linking, bacteriocidal
  • Penicillinase resistant
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4
Q

Penicillin + ß lactamase inhibitor: MOA

A
  • Stage 3 Cell Wall Synthesis: PG cross-linking, bacteriocidal
    • b-lactmase (resistance factor) inhibitor
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5
Q

Cephalosporins: MOA

A

Stage 3 Cell Wall Synthesis: PG cross-linking, bactericidal. Penicillinase resistant.

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6
Q

Carbapenems: MOA

A
  • Stage 3 Cell Wall Syntheis inhibition -
  • Bacteriocidal
  • Beta lactamase resistant
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7
Q

Monobactams: MOA

A

Stage 3 Cell Wall Synthesis: Peptidoglycan cross linking - Bacteriocidal

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8
Q

Vancomycin: MOA

A
  • Stage 2 Cell Wall Synthesis: Peptidoglycan Synthesis Polymerization
  • Binds D-ala d-ala of precursors
  • Bacteriocidal
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9
Q

Macrolides: MOA

A
  • Protein synthesis inhibition: 50S
  • Blocks translocation.
  • Bacteriostatic/cidal.
  • “MacroSlides”
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10
Q

Lincomycin: MOA

A

Protein Inhibition: 50S, Bacteriostatic

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11
Q

Oxazolidinones (Linezolid): MOA

A

Protein synthesis inhibition 50S, bacteriostatic (-cidal for strep)

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12
Q

Tetracylines: MOA

A
  • Protein Inhibition: 30S
  • Blocks A site tRNA binding
  • Bacteriostatic
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13
Q

Aminoglycosides: MOA

A

Protein Inhibition: 30S. Block formation of initiation complex. Bactericidal. Require O2 for uptake.

“A initiates the alphabet”

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14
Q

Metronidazole: MOA

A

Forms free radical toxic metabolites that damage DNA. Bacteriocidal.

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15
Q

Fluoroquinolones (-“oxacin”): MOA

A

DNA Gyrase Inhibition, bacteriocidal

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16
Q

Sulfonamides

A

PABA antimetabolites inhibit dihydropterate synthase, inhibitioning of Folic Acid biosynthesis, preventing DNA/RNA/Protein synthesis.

Bacteriocidal.

Trimethorprim inhibits dihydrofolate reductase.

17
Q

Nitrofurantoin: MOA

A

Damages DNA, bacteriostatic

18
Q

Bacteriostatic antibiotics

A

sulfonamides
trimethoprim
tetracyclines
macrolides
clindamycin
chloramphenicol

Infectious Disease: Unit 1 (17 decks)

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