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Pharmacology > Antimicrobial Pharmacology Session 5 > Flashcards

Antimicrobial Pharmacology Session 5 Flashcards

1
Q

Name of streptogramins

A

Dalfopristin

Quinupristin

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2
Q

Main path for disposal of streptogramins

A

Liver

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3
Q

Usage of streptogramins

A

Resistant strep and staphs

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4
Q

درمان آلودگی های staph aureus

A
  1. Cloxacillin and naficillin
  2. Vancomycin
  3. Quinupristin and Dalfopristin
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5
Q

E. Feacalis can cause?

A 
UTI
Bacteremia
Endocardit
Meningitis
Periodentitis
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6
Q

How to use streptogramins

A

تزریف وریدی با دکستروز

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7
Q

تداخلات streptogramins

A

Warfarin
Diazepam
Simvastatin

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8
Q

Linezolid features

A

جذب کامل گوارشی
نیمه عمر طولانی
نفوذ به CSF
دفع از کلیه

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9
Q

Usage of linezolid

A

Resistant strep staph and enterococ

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10
Q

Side effects of linezolid

A

آنمی
کاهش پلاکت
نوروپاتی
MAOI

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11
Q

Drugs in the group of lincozamides

A

Lincomycin

Clindomycin

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12
Q

Resistance mechanism to lincozamides

A

Binding site methylation

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13
Q

میزان نفوذ clindomycin

A

آبسه
زلالیه
استخوان
جفت و جنین

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14
Q

Treatment for toxoplasmosis encephalopathy

A

Clindomycin

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15
Q

Usage of clindomycin

A

باکتری های هوازی و بی‌هوازی
توکسوپلاسموز
مالاریا

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16
Q

Penicillin G alternative in endocarditis cases

A

Clindomycin

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17
Q

Drugs against Toxoplasmosis

A

Daraprim
Sulfadiazine

Spiramycin
Clindamycin

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18
Q

Toxic shock syndrome

A

Clindamycin and penicillin G

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19
Q

Alternative for co-trimoxazole in patients with HIV

A

Clindomycin

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20
Q

Side effect of clindomycin

A

عوارض گوارشی

کولیت با غشای کاذب (دیفیسیل)

21
Q

درمان کولیت با غشای کاذب (دیفیسیل)

A

Metronidazole

Vancomycin

22
Q

Alternatives of Clindamycin

A

Penicillin G
Chephalosporins
Macrolides

23
Q

درمان زردزخم impetigo

A

Mupirocin

24
Q

اثر بر روی ریبوزوم برای منع سنتز پروتئین

A

Mupirocin

25
Q

Natural macrolides

A

Erythromycin

Spiramycin

26
Q

Semisynthetic macrolides

A

Clarithromycin

Azithromycin

27
Q

Macrolide and immunosuppressive

A

Tacrilimus

28
Q

دارویی از ماکرولید ها که با غذا مصرف نمیشود

A

Azithromycin

29
Q

Usage of macrolides

A

Gram positive and negatives

Atypical organisms like mycoplasma and chlamidia

30
Q

Treatment of helicobacter pylori

A

Clarithromycin

Azithromycin

31
Q

Erythromycin and Azithromycin gram review

A

Erythromycin gram positive

Azithromycin gram negative

32
Q

Treatment of mycobacterium leprae

A

Clarithromycin

33
Q

مقاومت دارویی به ماکرولید

A

Active efflux یا کاهش نفوذپذیری
تولید آنزیم متیلازی
هیدرولیز (استراز)
موتاسیون کروموزومی

34
Q

مهم‌ترین مکانیسم مقاومت گرم‌مثبت‌ها

A

Efflux

متیلاز

35
Q

Alternative for macrolide resistance

A

Telithromycin

36
Q

داروی مصرفی دیفتری و سیاه‌سرفه

A

Erythromycin

37
Q

درمان گاستروپارازی

A

Macrolides

38
Q

درمان مایکوباکتریوم آویوم اینتراسلولار

A

Erythromycin

39
Q

درمان asymptomatic intestinal infection

Amebiasis

A

Paromomycin
OR
Erythromycin

40
Q

درمان NGU

A

Doxycyclin
OR
Azithromycin

41
Q

درمان شانکرویید

A

Ceftriaxone and ciprofloxacin
OR
Azithromycin

42
Q

درمان گاستروانتریت ناشی از campylobacter

A

Azithromycin

Erythromycin

43
Q

درمان کلامیدیا و toxoplasma

A

Macrolides (specially azithromycin)

44
Q

آثار آنتی‌باکتریال ماکرولیدها

A

ضد التهاب
کاهش تولید موکوس
فعال کردن گیرنده های موتیلینی

45
Q

Side effect of macrolides

A 
مشکلات گوارشی
یرقان
تشدید میاستنی
تشدید پورفریا
سندروم استیو جانسون
آریتمی
46
Q

تداخلات دارویی macrolides

A 
Warfarin
Theophylline
Cyclosporine
Digoxin
Cisapride
Methylprednisolone
  (افزایش جذاب) گریپ فروت
Sildenafil (cause hypotention)
47
Q

تداخلات chloramphenicol

A

Phenytoin

48
Q

Side effect of cloramphenicol

A

Anemia

Pharmacology (9 decks)

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