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Pharmacology > Antimicrobial Pharmacology Session 3 > Flashcards

Antimicrobial Pharmacology Session 3 Flashcards

1
Q

داروهای موثر بر دیواره سلولی چه زمانی بر باکتری تاثیرگذارند؟

A

در حال رشد

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2
Q

Don’t use cell wall related drugs with?

A

Bacteriostatics

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3
Q

داروهای ضدباکتری موثر بر سنتز دیواره [اسماشون]

A

Fosfomycin
Cycloserine
Bacitracin

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4
Q

محل اثر fosfomycin

A

سیتوپلاسم

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5
Q

Usage of fosfomycin

A

عفونت‌های قسمت تحتانی دستگاه ادراری و سیستیت

در آقایان: پروستاتیت

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6
Q

ساختار مشابه D-alanin

A

Cycloserine

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7
Q

Difference of cycloserine and cyclosporine

A

Antibacterial

Immunosuppressive

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8
Q

Usage of cycloserine

A

خط دوم درمان سل

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9
Q

علت عدم مصرف زیاد cycloserine

A

سمیت و cns و اعصاب محیطی مثل تشنج و سایکوز

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10
Q

Related to cell wall drugs with high nephrotoxicocity

A

Bacitracin

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11
Q

مکانیسم اثر bacitracin

A

مهار آنزیم فسفاتاز

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12
Q

انواع B-lactamها

A 
Penicillins
Cephalosporins
Carbapenems
Monobactems
B-lactamase inhibitors
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13
Q

گیرنده بتالاکتام‌ها

A

PBP

Penicillin binding pro

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14
Q

عبور یا عدم عبور B-lactamها از ع

غشا

A

نیاز به عبور ندارند و در فضای پری‌پلاسمیک هستن

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15
Q

اسم آنزیم‌های مهارشونده با بتالاکتام‌ها

A

Transpeptidaze

Autolyzin

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16
Q

روش‌های دیجاد مقاومت به B-lactams

A

کاهش ورود
تغییر در گیرنده
ترشح بتالاکتاماز

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17
Q

Penicilin G can’t enter which organisms?

A

Gram negatives

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18
Q

How are MRSs made?

A

Change in PBP proteins and resistance to B-lactams

Cefrbiprole
Ceftaroline
5th generation cephalosporins
Can damage MRSs

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19
Q

Groups of B-lactamases

A

Serini: have serine
Metalo: have Zn

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20
Q

Names of aminopenicilins

A

Amoxicilin

Ampicilin

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21
Q

Pseudomonas auroginosa effective penicillin

A

Piperacillin

22
Q

Groups of penicillins

A

Not large spectrum: penicillin G and mortabets
Staph related: methicilin, naficilin, oxacilin, cloxacilim
Large spectrum: amoxicilin, ampicilin, piperacilin

23
Q

Types of penicillin G

A

بنزیل

فنوکسی‌متیل

24
Q

در برابر اسید معده پایدار؟

A

فنوکسی متیل پنی‌سیلین

25
Q

Depo form of penicillin

A

Penicillin G procaine

26
Q

Strep groups

A

Alfa
Beta
Gamma

27
Q

Strep pyogen group and the disease that makes

A

B-Hemolytic

28
Q

Alfa hemolitics names of streps

A

Strep viridans

Strep pneumonia

29
Q

Strep viridans can cause?

A

Endocarditis

30
Q

Strep pneumonia can cause?

A

Pharengitis
Sinusitis
Otitis
Pneumonia

31
Q

Enterococ can cause?

A

Endocarditis
Pharengitis
Urinary tract infection

32
Q

Types of enterococs

A

Fecalis

Fascium

33
Q

Treat enterococ

A
  1. Ampicilin

2. Vancomycin

34
Q

Cause of Lyme disease?

A

برولیا بورگدوفری

35
Q

Listeria monocytogen can cause?

Best treat for it?

A

Menengitis
Endocarditis

Ampicillin

36
Q

Best treat for staph pharyngitis?

A

Penicillin G benzathine

37
Q

Treat for Penicillin resistant staph pharyngitis?

A

2nd generation Cephalosporins like ceftriaxone

Macrolides

38
Q

Penicillinase resistant penicillins

A

Methicilin
Naficilin
Cloxacillin

39
Q

Disposal of cloxacillin

A

Liver

40
Q

Aminopenicillins are?

A

Amoxicilin
Ampicillin

Large spectrum prnicillins

41
Q

Resistance mechanism of nisseria gonorrhoea to penicillins?

A

Make B-lactamase

42
Q

Usage of amoxicillin

A

Otitis media
Strep Pharyngitis
Sinusitis
Strep pneumonia

43
Q

Cause of UTI?

A

E. Coli (mostly resistant to penicillin)

44
Q

احیای داروهای
Amoxicillin
Ampicllin

A

Clavulanate sodium

Sulbactam

45
Q

Amoxicillin + clavulanate usage?

A

Urinary tract infections specially in pregnants

Otitis media

Sinusitis

46
Q

How to increase effectiveness of piperacillin?

A

+tazobactam

47
Q

Allergic reaction of penicillin is related to?

A

Age

48
Q

What causes hepatit?

A

Cloxacillin

49
Q

What causes nephritis?

A

Methicillin

50
Q

What causes neutropeni?

A

Naficillin

Methicillin

Pharmacology (9 decks)

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